Abstract
Black hairy tongue (BHT) developed in five patients (2.6%) among 192 patients undergoing chemotherapy for malignant brain tumors. Three patients with a history of diabetes mellitus developed BHT within 10 days after the initiation of chemotherapy. The other two patients suffered more than 100 days after induction and lymphopenia of grade 3 or worse developed for more than 20 days, which was not observed in the three patients with diabetes. We found that BHT could develop after chemotherapy for malignant brain tumors. Patients with diabetes mellitus presented early after chemotherapy, while patients with longstanding severe lymphopenia presented in late phase.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. While a series of treatment had been performed after obtaining appropriate written informed consent from the patients, additional written consent for inclusion of this study was waived by the institutional review board because of the retrospective and observational nature of the study.
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Yamagishi, Y., Maruyama, K., Kobayashi, K. et al. Black hairy tongue after chemotherapy for malignant brain tumors. Acta Neurochir 159, 169–172 (2017). https://doi.org/10.1007/s00701-016-3036-5
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DOI: https://doi.org/10.1007/s00701-016-3036-5