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Statistical shape analysis of temporal lobe in mesial temporal sclerosis patients

  • Clinical Article - Functional
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Abstract

Background

Surgery is regarded as a common treatment option for patients with mesial temporal lobe epilepsy due to hippocampal sclerosis but sometimes deciding this diagnosis can be very difficult. We aim to investigate the shape differences in the temporal lobe of mesial temporal sclerosis epilepsy patients compared with healthy controls, investigating the side difference and, if present, assessing the clinical application of this situation.

Method

The MRI scans of mesial TLE patients and controls were retrospectively reviewed. Temporal lobe data were collected from the two-dimensional digital images. Standard anthropometric landmarks were selected and marked on each digital image using TPSDIG 2.04 software. Eight anatomic landmarks were marked on images. A generalized Procrustes analysis was used to evaluate the shape difference. The shape deformation of the temporal lobe from control to patient was evaluated using the TPS method.

Results

There were statistically significant TL shape differences between groups. High level deformations for the left and right side from the control to patient group were seen in the TPS graphic. The highest deformation was determined at the inferior lateral temporal midpoint of the middle temporal gyri and superior temporal landmark points of both the right and left sides.

Conclusion

Our study for the first time demonstrated temporal shape differences in TLE patients using a landmark-based geometrical morphometric method by taking into consideration the topographic distribution of TL.

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References

  1. Baskan EB, Ercan I, Ozdemir ST, Ozkaya G, Yilmaz M, Ozgenel Y, Saricaoglu H (2013) A case of Parry-Romberg syndrome: examining efficacy of lipofilling by statistical shape analysis. Turk Klin J Med Sci 33:284–289

    Article  Google Scholar 

  2. Bookstein FL (1989) Principal warps: thin-plate splines and the decomposition of deformations. IEEE Trans Pattern Anal Mach Intell 11:567–585

    Article  Google Scholar 

  3. Bookstein FL (1991) Morphometrics tools for landmark data. Cambridge University Press, New York

    Google Scholar 

  4. Coste S, Ryvlin P, Hermier M, Ostrowsky K, Adeleine P, Froment JC, Mauguière F (2002) Temporopolar changes in temporal lobe epilepsy: a quantitative MRI-based study. Neurology 59:855–861

    Article  CAS  PubMed  Google Scholar 

  5. Dryden IL, Mardia KV (1998) Statistical shape analysis. Volume 4 1st ed. John Wiley & Sons pp 1-107

  6. Ercan I, Ocakoglu G, Guney I, Yazici B (2008) Adaptation of generalizability theory for inter-rater reliability for landmark localization. Int J Tomogr Stat 9:51–58

    Google Scholar 

  7. Ercan I, Ocakoglu G, Sigirli S, Ozkaya G (2012) Statistical shape analysis and usage in medical sciences: review. Turk Klin J Biostat 4:27–35

    Google Scholar 

  8. Etoz M, Ozdemir ST, Sigirli D, Demirbas AE, Ercan I, Etoz OA, Sisman Y (2013) Evaluation of bony structures on panoramic radiographs with statistical shape analysis in patients with temporomandibular joint pain and limited mouth opening. J Dent 3:495–500

    Google Scholar 

  9. Jeong SW, Lee SK, Hong KS, Kim KK, Chung CK, Kim H (2005) Prognostic factors for the surgery for mesial temporal lobe epilepsy: longitudinal analysis. Epilepsia 46:1273–1279

    Article  PubMed  Google Scholar 

  10. Lin JJ, Salamon N, Lee AD, Dutton RA, Geaga JA, Hayashi KM, Luders E, Toga AW, Engel J Jr, Thompson PM (2007) Reduced neocortical thickness and complexity mapped in mesial temporal lobe epilepsy with hippocampal sclerosis. Cereb Cortex 17:2007–2018

    Article  PubMed  Google Scholar 

  11. Lv RJ, Sun ZR, Cui T, Guan HZ, Ren HT, Shao XQ (2014) Temporal lobe epilepsy with amygdala enlargement: a subtype of temporal lobe epilepsy. BMC Neurol 14:194

    Article  PubMed Central  PubMed  Google Scholar 

  12. Mandell JG, Hill KL, Nguyen DT, Moser KW, Harbaugh RE, McInerney J, Nsubuga BK, Mugamba JK, Johnson D, Warf BC, Boling W, Webb AG, Schiff SJ (2014) Volumetric brain analysis in neurosurgery: Part 3. Volumetric CT analysis as a predictor of seizure outcome following temporal lobectomy. J Neurosurg Pediatr 28:1–11

    Google Scholar 

  13. Mathern GW, Babb TL, Armstrong DL (1997) Hippocampal sclerosis, In Epilepsy A comprehensive textbook. Lippincott-Raven. In: Engel J, Pedley TA, editors. 1. Philadelphia: Lippincott-Raven pp. 133–155

  14. Meiners LC, Witkamp TD, de Kort GA, van Huffelen AC, van der Graaf Y, Jansen GH, van der Grond J, van Veelen CW (1999) Relevance of temporal lobe white matter changes in hippocampal sclerosis. Magnetic resonance imaging and histology. Investig Radiol 34:38–45

    Article  CAS  Google Scholar 

  15. Ocakoglu G, Ozdemir ST, Ercan I, Etoz A (2013) The shape of the external human ear: a geometric morphometric study. Turk Klin J Med Sci 33:184–190

    Article  Google Scholar 

  16. Ocakoglu G, Ercan I (2014) Type I error rate for two-sample tests in statistical shape analysis. Hacet J Math Stat 41:141–152

    Google Scholar 

  17. Sigirli D, Ercan I, Ozdemir ST, Taskapilioglu O, Hakyemez B, Turan OF (2012) Shape analysis of the corpus callosum and the cerebellum in female MS patients with different clinical phenotypes. Anat Rec 2957:1202–1211

    Article  Google Scholar 

  18. Thom M, Eriksson S, Martinian L, Caboclo LO, McEvoy AW, Duncan JS, Sisodiya SM (2009) Temporal lobe sclerosis associated with hippocampal sclerosis in temporal lobe epilepsy: neuropathological features. J Neuropathol Exp Neurol 68:928–938

    Article  PubMed Central  PubMed  Google Scholar 

  19. Thom M, Mathern GW, Cross JH, Bertram EH (2010) Mesial temporal lobe epilepsy: how do we improve surgical outcome? Ann Neurol 68:424–434

    Article  PubMed Central  PubMed  Google Scholar 

  20. Yoon HH, Kwon HL, Mattson RH, Spencer DD, Spencer SS (2003) Long-term seizure outcome in patients initially seizure free after resective epilepsy surgery. Neurology 61:445–450

    Article  CAS  PubMed  Google Scholar 

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Conflict of interest

All authors certify that they have NO affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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Authors and Affiliations

  1. Department of Biostatistics, Faculty of Medicine, Uludag University, Bursa, Turkey

    Gokhan Ocakoglu & Ilker Ercan

  2. Department of Neurosurgery, Faculty of Medicine, Uludag University, Bursa, Turkey

    M. Ozgur Taskapilioglu & Ahmet Bekar

  3. Department of Neurology, Faculty of Medicine, Uludag University, Bursa, Turkey

    Aylin Bican Demir & Ibrahim Bora

  4. Department of Radiology, Faculty of Medicine, Uludag University, Bursa, Turkey

    Bahattin Hakyemez

Authors
  1. Gokhan Ocakoglu
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  2. M. Ozgur Taskapilioglu
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  3. Ilker Ercan
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  4. Aylin Bican Demir
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  5. Bahattin Hakyemez
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  6. Ahmet Bekar
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  7. Ibrahim Bora
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Corresponding author

Correspondence to Gokhan Ocakoglu.

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Comment

This is a well-written and -structured article describing a method of statistical shape analysis in mesial temporal sclerosis patients (MTLS). The development of more and more automatized methods for analysis of MRI findings is interesting and will probably become more important and a more natural part of the presurgical workup in the future. In the present article the method does not really reveal new findings, but the authors illustrate nicely that this method is able to detect the changes related to MTLS in an automatized way. The method is advanced, and I think that this and similar methods will be clinically important and relevant in the near future. I recommend following this development closely.

Bertil Rydenhag

Gothenburg, Sweden

Temporal lobe epilepsy is associated with structural changes and the functional isolation of the ipsilateral temporal lobe. These changes seem to be time related and secondary to progressive atrophy of both the neocortical and mesial parts of the temporal lobe. The structural changes (atrophy) may indicate impaired functional connectivity. TLE with HS seems to limit these volumetric/functional changes to the ipsilateral temporal lobe, and in case of CD associated with TLE, the changes seem to be bilateral. The authors of the present study offer a relatively simple method to assess volumetric and shape changes in TLE; this in conjuction with advanced MRI imaging (DTI,fMRI, etc.) can potentially offer epilepsy surgeons a useful and simple tool to assess the temporal lobe morphology. Larger studies can link those changes to the functionality and connectivity of the temporal lobe.

Jibril Osman Farah

Liverpool, UK

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Ocakoglu, G., Taskapilioglu, M.O., Ercan, I. et al. Statistical shape analysis of temporal lobe in mesial temporal sclerosis patients. Acta Neurochir 157, 1897–1903 (2015). https://doi.org/10.1007/s00701-015-2555-9

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  • DOI: https://doi.org/10.1007/s00701-015-2555-9

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