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Admission B-type natriuretic peptide levels are associated with in-hospital cardiac events in patients with intracranial hemorrhage

  • Clinical Article - Vascular
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Abstract

Background

Intracranial hemorrhage (ICH) is often associated with cardiac events. Twelve-lead electrocardiography (ECG) and transthoracic echocardiography are essential diagnostic tools for preoperative risk assessment. B-type natriuretic peptide (BNP) is a well-known predictor of cardiac outcome in various clinical settings. This study examined whether BNP levels on admission are associated with in-hospital cardiac events among ICH patients.

Method

This prospective study enrolled 77 ICH patients who were admitted to this hospital for emergency neurosurgery. On admission, BNP levels, 12-lead ECG and transthoracic echocardiography were carried out for all patients. These patients were divided into two groups: Group I included 19 patients (10 men and 9 women) having 24 in-hospital cardiac events (mean age of 57 ± 15 years); Group II included 57 patients (29 men, mean age of 71 ± 11 years) without cardiac events.

Results

Admission BNP levels of Group I patients were significantly higher than those of Group II patients (683.8 ± 1,043.8 pg/ml vs 168.5 ± 173.5 pg/ml, p = 0.001). In multivariate analysis, BNP levels and T-wave inversion are independent predictors of in-hospital cardiac events. A cutoff value of BNP levels (156.6 pg/ml) predicted in-hospital cardiac events in ICH patients with 80 % sensitivity and 66 % specificity.

Conclusions

Serum BNP levels and electrocardiographic T-wave inversion on admission are independent predictors of in-hospital cardiac events in patients with ICH who undergo emergency neurosurgery.

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Authors and Affiliations

  1. Department of Cardiology, Incheon-Naun Hospital, Incheon, Korea

    Jae Hong Park

  2. Heart Institute, Asan Medical Center, University of Ulsan College of Medicine, 43-Gil, 88 Olympic-Ro, Songpa-Gu, Seoul, Korea

    Yoo Ri Kim & Gi-Byoung Nam

  3. Department of Neurosurgery, Kang Nam General Hospital, Yong-In, Korea

    Seung Hyun Kim

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  1. Jae Hong Park
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  2. Yoo Ri Kim
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  3. Seung Hyun Kim
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  4. Gi-Byoung Nam
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Correspondence to Gi-Byoung Nam.

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J.H. Park and Y.R. Kim contributed equally to this article

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Park, J.H., Kim, Y.R., Kim, S.H. et al. Admission B-type natriuretic peptide levels are associated with in-hospital cardiac events in patients with intracranial hemorrhage. Acta Neurochir 157, 21–27 (2015). https://doi.org/10.1007/s00701-014-2260-0

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  • DOI: https://doi.org/10.1007/s00701-014-2260-0

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