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Simultaneous voltammetric determination of dopamine and uric acid using carbon-encapsulated hollow Fe3O4 nanoparticles anchored to an electrode modified with nanosheets of reduced graphene oxide

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Abstract

The authors describe an electrochemical sensor for simultaneous determination of dopamine (DA) and uric acid (UA). The sensor is based on the use of composite materials of carbon-encapsulated hollow magnetite (Fe3O4) nanoparticles and graphene oxide nanosheets, which were homogeneously deposited on a glassy carbon electrode. The morphology of the materials was characterized by transmission electron microscopy and scanning electron microscopy, and the properties of differently decorated electrodes were investigated via cyclic voltammetry and differential pulse voltammetry (DPV). Simultaneous detection of DA and UA was carried out via DPV, and the potentials of electrooxidation peaks are 0.14 V and 0.27 V (vs. SCE) for DA and UA, respectively. The calibration plot is linear from 0.1 to 150 μM for DA, and from 1.0 to 100 μM for UA, with detection limits of 0.053 μM and 0.41 μM at an S/N ratio of 3. The method was applied to the quantification of DA and UA in brain tissue, urine and whole blood.

Schematic of an electrochemical sensor for simultaneous voltammetric determination of dopamine (DA) and uric acid (UA) using 3D carbon-encapsulated hollow Fe3O4 nanoparticles (H-Fe3O4@C) anchored on graphene nanosheet (GNS) modified glassy carbon electrode (GCE).

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Acknowledgements

The project financially supported by the Major Program for Science and Technology Development of Shihezi University (gxjs2014-zdgg04), National Natural Science Foundation of China (81260487, 81460543, 21575089), the Scientific Research Foundation for the Returned Overseas Chinese Scholars from Ministry of Human Resources and Social Security of China (RSLX201301), the Pairing Program of Shihezi University with Eminent Scholar in Elite University (SDJDZ201502), open Funding Project of the State Key Laboratory of Bioreactor Engineering and 2015 Key Technical Innovation Project of Xinjiang Uygur Autonomous Region.

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Authors and Affiliations

  1. Key Laboratory of Xinjiang Phytomedicine Resources for Ministry of Education, School of Pharmacy, Shihezi University, Shihezi, 832000, China

    Han Song, Guipeng Xue, Junjie Zhang, Shiguo Sun, Liping Tian & Yingchun Li

  2. Xinjiang Institute of Materia Medica/Key Laboratory of Xinjiang Uygur Medicine, Urumqi, 830004, China

    Guipeng Xue

  3. Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi, 832003, China

    Gang Wang, Bang-Ce Ye & Yingchun Li

  4. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China

    Bang-Ce Ye

  5. School of Natural Sciences and Humanities, Harbin Institute of Technology, Shenzhen, 518055, China

    Yingchun Li

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  1. Han Song
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  2. Guipeng Xue
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Correspondence to Gang Wang or Yingchun Li.

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Han Song and Guipeng Xue contributed equally to this study.

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Song, H., Xue, G., Zhang, J. et al. Simultaneous voltammetric determination of dopamine and uric acid using carbon-encapsulated hollow Fe3O4 nanoparticles anchored to an electrode modified with nanosheets of reduced graphene oxide. Microchim Acta 184, 843–853 (2017). https://doi.org/10.1007/s00604-016-2067-1

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  • DOI: https://doi.org/10.1007/s00604-016-2067-1

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