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Voltammetric uric acid sensor based on a glassy carbon electrode modified with a nanocomposite consisting of polytetraphenylporphyrin, polypyrrole, and graphene oxide

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Abstract

The article describes an electrochemical sensor for the detection of uric acid (UA) by using a glassy carbon electrode (GCE) modified with a composite consisting of polytetraphenylporphyrin, polypyrrole, and graphene oxide. The PPy/GO nanocomposites were synthesized by in-situ chemical oxidation polymerization. Microspheres loaded with p-TPP were mixed into the PPy/GO nanocomposite, deposited on the GCE and dried upon which aggregation occurs. The nanocomposites were characterized by scanning electron microscopy, FTIR and Raman spectroscopy. The sensor was applied to the voltammetric determination of UA by differential pulse voltammetry (DPV). The oxidation current varies with the UA concentration in the range from 5 to 200 μM, and electrochemical response is distinctly improved compared to GCEs modified with p-TPP or PPy/GO only. The modified electrode shows excellent linearity, lower detection limit of 1.15 μM. The results also demonstrate that the modified electrode exhibited good selectivity and sensitivity toward UA even in the presence of AA and DA.

An electrochemical sensor was researched for selectivity detecting uric acid (UA) by using polytetraphenylporphyrin/polypyrrole/graphene oxide (p-TPP/PPy/GO) composites modified electrode.

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Acknowledgments

This work was supported by the Fundamental Research Funds of Shandong University (2015HW019), and the National Natural Science Foundation of China (21373129).

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Authors and Affiliations

  1. Key Laboratory for Colloid and Interface Chemistry of State Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, China

    Hongxiu Dai, Nan Wang, Donglei Wang, Xiaomei Zhang, Houyi Ma & Meng Lin

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  1. Hongxiu Dai
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  2. Nan Wang
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  3. Donglei Wang
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  4. Xiaomei Zhang
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  5. Houyi Ma
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  6. Meng Lin
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Correspondence to Meng Lin.

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Dai, H., Wang, N., Wang, D. et al. Voltammetric uric acid sensor based on a glassy carbon electrode modified with a nanocomposite consisting of polytetraphenylporphyrin, polypyrrole, and graphene oxide. Microchim Acta 183, 3053–3059 (2016). https://doi.org/10.1007/s00604-016-1953-x

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  • DOI: https://doi.org/10.1007/s00604-016-1953-x

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