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Magnetic porous carbon derived from a zinc-cobalt metal-organic framework: A adsorbent for magnetic solid phase extraction of flunitrazepam

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Abstract

Nanoporous carbon that contains magnetic cobalt nanoparticles (Co-NPC) was fabricated by direct carbonization of a Zn-Co bimetallic zeolitic imidazolate framework. After carbonization, the magnetic Co-NPs are well dispersed in the porous carbon matrix, with the result that the Co-NPC displays strong magnetism. The Co-NPC possesses a high specific surface area, large pore volumes and a microstructure comprised of mesopores and macropores. This results in fast molecular diffusion of the analytes along with excellent adsorption. The Co-NPC was used as a magnetic adsorbent for the enrichment of the benzodiazepine drug flunitrazepam (rohypnol) from tea and Ginger ale prior to high-resolution mass spectrometric analysis. The calibration plot is linear (with a correlation coefficient of >0.9869) in the 1 to 500 ng mL−1 concentration range. The limits of detection are 0.2 ng mL−1 for Ginger ale and 1.0 ngmL−1 for Arizona Tea samples, respectively, which is lower by about 4 orders of magnitude than those reported in the literature.

Magnetic nanoporous carbon was fabricated by direct carbonization of Zn-Co zeolitic imidazolate framework. It was used as a magnetic solid-phase extraction adsorbent for the preconcentration of flunitrazepam from beverage samples prior to its determination by high resolution mass spectrometry.

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Acknowledgments

Financial supports from Program of Study Abroad for Young Teachers by Agricultural University of Hebei, NSF Career Award (CHE-1149367), and NSF IDBR (CHE-1455554), the National Natural Science Foundation of China (31471643, 31671930), the Natural Science Foundation of Hebei Province (B2016204136), the Scientific and Technological Research Foundation of the Department of Education of Hebei Province (ZD2016085) are gratefully acknowledged.

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Correspondence to Qiuhua Wu or Chen Hao.

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Qiuhua Wu and Si Cheng contributed equally to this work.

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Wu, Q., Cheng, S., Wang, C. et al. Magnetic porous carbon derived from a zinc-cobalt metal-organic framework: A adsorbent for magnetic solid phase extraction of flunitrazepam. Microchim Acta 183, 3009–3017 (2016). https://doi.org/10.1007/s00604-016-1948-7

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  • DOI: https://doi.org/10.1007/s00604-016-1948-7

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