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Simultaneous determination of acetaminophen, theophylline and caffeine using a glassy carbon disk electrode modified with a composite consisting of poly(Alizarin Violet 3B), multiwalled carbon nanotubes and graphene

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Abstract

The authors describe a glassy carbon disk electrode which after modification with poly(Alizarin Violet 3B), multiwalled carbon nanotubes and graphene enables simultaneous determination of the drugs acetaminophen (AP), theophylline (TP) and caffeine (CF). The electrochemical response to AP, TP and CF at the modified electrode was studied by cyclic voltammetry, and the results revealed an excellent electrocatalytic activity towards the oxidation of the three analytes at potentials of typically 0.5, 1.15 and 1.4 V (vs. SCE) respectively. The anodic peaks are well defined and occur at lower oxidation potential and enhanced oxidation peak currents (compared to an unmodified electrode). Simultaneous differential pulse voltammetric measurements resulted in calibration plot for AP, TP and CF were obtained that cover range from 0.2 to 100 μM for AP, from 0.5 to 120 μM for TP, and from 1.0 to 120 μM for CF. The respective detection limits are 0.01, 0.02 and 0.10 μM. The method was applied to simultaneous determination of AP, TP and CF in spiked human serum and gave satisfactory results.

A nanocomposite consisting of poly(Alizarin violet), multiwalled carbon nanotubes and graphene was used to modify a glassy carbon electrode which then can be used simultaneously determine acetaminophen, theophylline and caffeine.

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Acknowledgments

The research presented in this manuscript was supported by the Natural Science Foundation of Shandong Province of China (Y2006B28).

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Authors and Affiliations

  1. College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan, 250014, People’s Republic of China

    Yan Wang, Ting Wu & Chun-yan Bi

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  1. Yan Wang
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  2. Ting Wu
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  3. Chun-yan Bi
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Correspondence to Yan Wang.

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Wang, Y., Wu, T. & Bi, Cy. Simultaneous determination of acetaminophen, theophylline and caffeine using a glassy carbon disk electrode modified with a composite consisting of poly(Alizarin Violet 3B), multiwalled carbon nanotubes and graphene. Microchim Acta 183, 731–739 (2016). https://doi.org/10.1007/s00604-015-1688-0

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  • DOI: https://doi.org/10.1007/s00604-015-1688-0

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