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Repair of gastric defects with an equine pericardial patch

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Abstract

Purposes

The objective of this study was to test the efficacy of an equine pericardial patch for repairing full-thickness defects of the stomach wall.

Methods

Circular defects, 1.5 cm in diameter, were created on the anterior wall of the stomach of 12 female New Zealand rabbits. The defects were repaired by an equine pericardial patch. After euthanasia at different time intervals (3 days to 8 weeks) a macroscopic evaluation of the abdominal cavity (including adhesion scoring), mechanical testing and a histological examination of the stomach were performed.

Results

The animals survived the surgical procedure and underwent an uneventful recovery until euthanasia. None of the patches failed. Adhesions were observed in all animals and were significant in 3/12 animals. Bursting pressure testing indicated that the repair was durable and that adequate strength to prevent patch failure was achieved by the second week. A histological examination showed gradual narrowing of the perforation site by mucosal and limited muscular regeneration.

Conclusions

The equine pericardial patch was successfully used to repair a gastric defect in our experimental model, and it seems that it could have potential as a material suitable for further research concerning the repair of upper gastrointestinal defects.

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Acknowledgments

The authors would like to thank Prof. Despina Perrea Director of the “N.S. Christeas” Laboratory for Experimental Surgery and Surgical Research, at the University of Athens Medical School, where the experimental surgical procedures took place and Dr. Alkistis Pantopoulou who was the supervising veterinarian. We would also like to thank Prof. Stavros Kourkoulis and Mr. Athanasios Mitousoudis from the National Technical University of Athens for the bursting pressure measurements and Ms. Myrto Kogevina for the editing of the manuscript. This work was supported by a University of Athens research grant (Kapodistrias programme).

Conflict of interest

Doctors Kostantinos Spiliopoulos, Charalampos Markakis, Periklis Tomos, Hariklia Gakiopoulou, Ioannis Nikolopoulos, Eleftherios Spartalis, Kostantinos Kontzoglou and Michael Safioleas have no conflicts of interest or financial ties to disclose.

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Authors and Affiliations

  1. Second Propaedeutic Department of Surgery, Thoracic Surgery Department, University of Athens, “Laiko” General Hospital, 17 Agiou Thoma Str., 11527, Athens, Greece

    Kostantinos Spiliopoulos, Charalampos Markakis, Periklis Tomos, Eleftherios Spartalis, Kostantinos Kontzoglou & Michael Safioleas

  2. Department of Surgery, Queen Elizabeth Hospital Woolwich, London, UK

    Charalampos Markakis & Ioannis Nikolopoulos

  3. Department of Pathology, University of Athens, “Laiko” General Hospital, Athens, Greece

    Hariklia Gakiopoulou

Authors
  1. Kostantinos Spiliopoulos
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  2. Charalampos Markakis
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  3. Periklis Tomos
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  4. Hariklia Gakiopoulou
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Corresponding author

Correspondence to Charalampos Markakis.

Additional information

K. Spiliopoulos and C. Markakis made equal contribution to this study.

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Spiliopoulos, K., Markakis, C., Tomos, P. et al. Repair of gastric defects with an equine pericardial patch. Surg Today 45, 83–90 (2015). https://doi.org/10.1007/s00595-014-1072-4

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  • DOI: https://doi.org/10.1007/s00595-014-1072-4

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