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Serum ghrelin levels partially recover with the recovery of appetite and food intake after total gastrectomy

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Abstract

Purpose

Ghrelin may lead to weight gain by appetite stimulation. This prospective study investigated the association between weight loss and the ghrelin levels in patients after gastrectomy.

Methods

Thirty-three males and eight females were enrolled in the study. The average age was 66 years. Measurements of the serum ghrelin level and an appetite questionnaire were performed preoperatively and at one, three, six and 12 months postoperatively.

Results

The preoperative serum total ghrelin level was 51.6 ± 31.9 (fmol/ml ± SD), and that at one, three, six and 12 months postoperatively was 16.9 ± 9.0, 21.2 ± 16.0, 28.0 ± 19.1 and 29.6 ± 20.6 (fmol/ml ± SD), respectively. The appetite score was 2.02 ± 1.09 points at 1 month, and increased significantly to 2.61 ± 1.00 by 12 months.

Conclusions

The ghrelin levels were reduced after gastrectomy and did not recover by 12 months postoperatively. Further studies are needed to evaluate these results as the basis of a therapeutic trial.

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Conflict of interest

None of the authors has any conflict of interest to declare.

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Authors and Affiliations

  1. Department of Surgery, Jichi Medical University School of Medicine, Yakushiji 3311-1, Shimotsuke, Tochigi, 329-0498, Japan

    Masaru Koizumi, Yoshinori Hosoya, Hideo Nagai, Alan T. Lefor, Naohiro Sata & Yoshikazu Yasuda

  2. Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Yakushiji 3311-1, Shimotsuke, Tochigi, 329-0498, Japan

    Masaru Koizumi, Katsuya Dezaki & Toshihiko Yada

  3. Department of Biochemistry, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Osaka, Suita, 565-8565, Japan

    Hiroshi Hosoda & Kenji Kangawa

  4. Department of Surgery, Ibaraki Prefectural Central Hospital, Koibuchi 6528, Ibaraki, Kasama, 309-1793, Japan

    Hideo Nagai

Authors
  1. Masaru Koizumi
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  2. Yoshinori Hosoya
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  3. Katsuya Dezaki
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  4. Toshihiko Yada
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  5. Hiroshi Hosoda
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  6. Kenji Kangawa
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  7. Hideo Nagai
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  8. Alan T. Lefor
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  9. Naohiro Sata
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  10. Yoshikazu Yasuda
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Corresponding author

Correspondence to Alan T. Lefor.

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Koizumi, M., Hosoya, Y., Dezaki, K. et al. Serum ghrelin levels partially recover with the recovery of appetite and food intake after total gastrectomy. Surg Today 44, 2131–2137 (2014). https://doi.org/10.1007/s00595-014-0873-9

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  • DOI: https://doi.org/10.1007/s00595-014-0873-9

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