Original Article

Surgery Today

, Volume 43, Issue 8, pp 865-870

Postoperative outcomes of patients with hepatocellular carcinoma negative for all virus-related markers

  • Ichiro YamatoAffiliated withDepartment of Digestive Surgery, Nihon University School of MedicineDepartment of Surgery, Nara Medical University
  • , Tadatoshi TakayamaAffiliated withDepartment of Digestive Surgery, Nihon University School of Medicine Email author 
  • , Yutaka MidorikawaAffiliated withDepartment of Digestive Surgery, Nihon University School of Medicine
  • , Tokio HigakiAffiliated withDepartment of Digestive Surgery, Nihon University School of Medicine
  • , Hisashi NakayamaAffiliated withDepartment of Digestive Surgery, Nihon University School of Medicine
  • , Masamichi MoriguchiAffiliated withDepartment of Digestive Surgery, Nihon University School of Medicine
  • , Yoshiyuki NakajimaAffiliated withDepartment of Surgery, Nara Medical University
  • , Shunichi MatsuokaAffiliated withDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine
  • , Masahiro OgawaAffiliated withDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine
    • , Mitsuhiko MoriyamaAffiliated withDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine

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Abstract

Purpose

The outcomes of patients with resectable hepatocellular carcinoma (HCC) negative for all virus-related markers have not yet been characterized. This study investigated the outcomes of such patients in comparison to those who had virus-related resectable HCC.

Methods

A total of 398 patients with HCC were divided into 2 groups, comprising patients in which all virus-related markers (HBs-Ag, HBs-Ab, HBe-Ag, HBe-Ab, HBc-Ab, HCV-Ab) were negative (all-negative group, n = 63) and those with at least 1 positive virus-related marker (virus-related group, n = 335). The clinical characteristics, surgical data, and survival rates were compared between the groups.

Results

The serum AST (30 vs. 45 IU/l, P < 0.0001) and ALT (21 vs. 42 IU/l, P < 0.0001) levels were significantly lower in the all-negative group than in the virus-related group. The tumor size (4.3 vs. 3.1 cm, P < 0.0001), the prevalence of DM (46.8 vs. 25.4 %, P = 0.001), and BMI (24.8 vs. 22.9, P = 0.0023) were significantly higher in the all-negative group than in the virus-related group. HCC arose from a cirrhotic liver in a significantly higher proportion of patients in the virus-related group than in the all-negative group (20.6 vs. 44.8 %, P = 0.0002). The survival outcomes were not significantly different in the 2 groups (all-negative vs. virus-related: 5-year overall survival rate, 58.2 vs. 55.2 %, P = 0.27), despite such differences in the patients’ characteristics.

Conclusions

The postoperative outcomes of patients with HCC are independent of the presence or absence of hepatitis viral infection.

Keywords

Hepatocellular carcinoma All negative Virus-related marker Non-B non-C Outcome