Surgery Today

, Volume 39, Issue 7, pp 587–591

Aloe versus silver sulfadiazine creams for second-degree burns: A randomized controlled study

  • Ghasemali Khorasani
  • Seyed Jalal Hosseinimehr
  • Mohammad Azadbakht
  • Arman Zamani
  • Mohammad Reza Mahdavi
Original Article

DOI: 10.1007/s00595-008-3944-y

Cite this article as:
Khorasani, G., Hosseinimehr, S.J., Azadbakht, M. et al. Surg Today (2009) 39: 587. doi:10.1007/s00595-008-3944-y



Burn injury is associated with a high incidence of death and disability; yet its management remains problematic and costly. We conducted this clinical study to evaluate the efficacy of aloe vera cream for partial thickness burn wounds and compare its results with those of silver sulfadiazine (SSD).


Thirty patients with similar types of second-degree burns at two sites on different parts of the body were included in this study. Each patient had one burn treated with topical SSD and one treated with aloe cream, randomly.


The rate of re-epithelialization and healing of the partial thickness burns was significantly faster in the site treated with aloe than in the site treated with SSD (15.9 ± 2 vs 18.73 ± 2.65 days, respectively; P < 0.0001). The sites treated with aloe were completely healed in less than 16 days vs 19 days for the sites treated with SSD.


These results clearly demonstrated the greater efficacy of aloe cream over SSD cream for treating second-degree burns.

Key words

BurnAloe veraWoundSilver sulfadiazine

Copyright information

© Springer 2009

Authors and Affiliations

  • Ghasemali Khorasani
    • 1
    • 6
  • Seyed Jalal Hosseinimehr
    • 2
    • 3
  • Mohammad Azadbakht
    • 4
  • Arman Zamani
    • 1
  • Mohammad Reza Mahdavi
    • 5
  1. 1.Department of Surgery, Faculty of MedicineMazandaran University of Medical SciencesSariIran
  2. 2.Department of Medicinal Chemistry, Faculty of PharmacyMazandaran University of Medical SciencesSariIran
  3. 3.Pharmaceutical Research CenterMazandaran University of Medical SciencesSariIran
  4. 4.Department of Pharmacognosy, Faculty of PharmacyMazandaran University of Medical SciencesSariIran
  5. 5.Department of Clinical Laboratory, Faculty of Paramedical SciencesMazandaran University of Medical SciencesSariIran
  6. 6.Faculty of MedicineTehran University of Medical SciencesTehranIran