Original Article

Surgery Today

, Volume 39, Issue 7, pp 587-591

Aloe versus silver sulfadiazine creams for second-degree burns: A randomized controlled study

  • Ghasemali KhorasaniAffiliated withDepartment of Surgery, Faculty of Medicine, Mazandaran University of Medical SciencesFaculty of Medicine, Tehran University of Medical Sciences
  • , Seyed Jalal HosseinimehrAffiliated withDepartment of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical SciencesPharmaceutical Research Center, Mazandaran University of Medical Sciences Email author 
  • , Mohammad AzadbakhtAffiliated withDepartment of Pharmacognosy, Faculty of Pharmacy, Mazandaran University of Medical Sciences
  • , Arman ZamaniAffiliated withDepartment of Surgery, Faculty of Medicine, Mazandaran University of Medical Sciences
  • , Mohammad Reza MahdaviAffiliated withDepartment of Clinical Laboratory, Faculty of Paramedical Sciences, Mazandaran University of Medical Sciences

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Abstract

Purpose

Burn injury is associated with a high incidence of death and disability; yet its management remains problematic and costly. We conducted this clinical study to evaluate the efficacy of aloe vera cream for partial thickness burn wounds and compare its results with those of silver sulfadiazine (SSD).

Methods

Thirty patients with similar types of second-degree burns at two sites on different parts of the body were included in this study. Each patient had one burn treated with topical SSD and one treated with aloe cream, randomly.

Results

The rate of re-epithelialization and healing of the partial thickness burns was significantly faster in the site treated with aloe than in the site treated with SSD (15.9 ± 2 vs 18.73 ± 2.65 days, respectively; P < 0.0001). The sites treated with aloe were completely healed in less than 16 days vs 19 days for the sites treated with SSD.

Conclusion

These results clearly demonstrated the greater efficacy of aloe cream over SSD cream for treating second-degree burns.

Key words

Burn Aloe vera Wound Silver sulfadiazine