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The influence of type 2 diabetes and arterial hypertension on right ventricular layer-specific mechanics

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Abstract

Aims

The aim of the investigation was to evaluate layer-specific right ventricular (RV) deformation in normotensive and hypertensive subjects with type 2 diabetes mellitus (DM).

Methods

This cross-sectional study included 129 subjects (40 controls, 42 normotensive DM and 47 hypertensive DM patients) who underwent complete two-dimensional echocardiographic examination (2DE) including multilayer strain analysis.

Results

2DE RV global and free wall longitudinal strains were reduced in normotensive and hypertensive DM subjects than in controls. RV global longitudinal layer-specific strains (endo-, mid- and epicardial) were lower in normotensive and hypertensive DM patients than in controls. On the other side, layer-specific strains of RV free wall were lower in hypertensive DM patients than in controls, without significant difference between controls and normotensive DM subjects. Parameters of DM control (fasting glucose and glycosylated hemoglobin) were associated with 2DE RV global longitudinal endo- and mid-myocardial layer strain.

Conclusions

Diabetes and hypertension significantly influence RV mechanics assessed by 2DE conventional and 2DE multilayer strain. Hypertension has an additive unfavorable influence on RV deformation in diabetic patients. Laboratory parameters of diabetic control were associated with RV structure, diastolic function and mechanics assessed with complex 2DE strain analysis.

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Authors and Affiliations

  1. Department of Cardiology, University Hospital “Dr Dragisa Misovic - Dedinje”, Heroja Milana Tepica 1, Belgrade, 11000, Serbia

    Marijana Tadic, Vladan Vukomanovic, Vera Celic & Vesna Kocijancic

  2. Department of Endocrinology, University Hospital “Dr Dragisa Misovic - Dedinje”, Heroja Milana Tepica 1, Belgrade, 11000, Serbia

    Sanja Ilic

  3. Clinical Research Unit, University of Milan-Bicocca and Istituto Auxologico Italiano, Viale della Resistenza 23, 20036, Meda, Italy

    Cesare Cuspidi

  4. Faculty of Medicine, Doktora Subotica 6, Belgrade, 11000, Serbia

    Marijana Tadic & Vera Celic

  5. Faculty of Health Sciences, LAPEC EA4278, Avignon University, 84000, Avignon, France

    Philippe Obert

Authors
  1. Marijana Tadic
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  2. Cesare Cuspidi
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  3. Vladan Vukomanovic
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  4. Sanja Ilic
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  5. Vera Celic
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  6. Philippe Obert
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  7. Vesna Kocijancic
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Corresponding author

Correspondence to Marijana Tadic.

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Conflict of interest

The authors declare that they have no conflict of interest.

Human and animal rights

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008 (5).

Informed consent

Informed consent was obtained from all patients for being included in the study.

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Managed by Massimo Porta.

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Tadic, M., Cuspidi, C., Vukomanovic, V. et al. The influence of type 2 diabetes and arterial hypertension on right ventricular layer-specific mechanics. Acta Diabetol 53, 791–797 (2016). https://doi.org/10.1007/s00592-016-0874-9

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  • DOI: https://doi.org/10.1007/s00592-016-0874-9

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