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High-sensitivity C-reactive protein, but not white blood cell count, independently predicted incident diabetes in a Japanese health screening population

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Abstract

Aims

To compare high-sensitivity C-reactive protein (hs-CRP) and white blood cell count (WBC) as a predictor of incident diabetes in a population where obesity is not prevalent.

Methods

This is a retrospective 6-year follow-up study in a Japanese health screening population including 1874 men and 1094 women. Using Cox regression methods, hazard ratios (HRs) of incident diabetes for hs-CRP and WBC adjusting for fasting plasma glucose (FPG), hemoglobin A1c (HbA1c) and other confounders were calculated, and using areas under receiver operating characteristic curve (AUCs), diabetes-predicting abilities of hs-CRP and WBC were compared. Diabetes was defined as FPG ≥ 126 mg/dL and HbA1c ≥ 6.5 % or use of antidiabetic medication.

Results

During the 6-year follow-up period (mean ± SD, 4.8 ± 1.7 years), 71 men (3.8 %) and 19 women (1.7 %) developed incident diabetes. The fully adjusted HRs [95 % confidence intervals (CIs)] of incident diabetes for each 1 SD increase in log hs-CRP and WBC were 1.20 (0.92–1.56) (p = 0.174) and 1.01 (0.78–1.30) (p = 0.946), respectively. The fully adjusted HRs (95 % CIs) of incident diabetes for the highest tertile of hs-CRP and WBC compared with the lowest tertile were 2.57 (1.05–6.27) (p = 0.039) and 1.20 (0.53–2.70) (p = 0.665), respectively. The AUCs (95 % CIs) of hs-CRP and WBC for the discrimination of incident diabetes were 0.73 (0.68–0.77) and 0.67 (0.62–0.72), respectively.

Conclusions

Hs-CRP, but not WBC, was independently associated with incident diabetes in a Japanese health screening population where obesity is not prevalent.

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Acknowledgments

The author thanks all subjects who participated in the study, the paramedical staff at our center who assisted with the study and Honorary Prof. Yoshifusa Aizawa at Tachikawa Medical Center for his valuable comments.

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Authors and Affiliations

  1. Medical Check-up Center, Tachikawa Medical Center, Nagachou 2-2-16, Nagaoka, Niigata, 940-0053, Japan

    Eiji Oda

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  1. Eiji Oda
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Correspondence to Eiji Oda.

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Funding

The sole author, Oda E, received no financial support.

Conflict of interest

The sole author, Oda E, declared that he has no conflict of interest.

Ethical standard

This study was carried out in accordance with the principles of the Declaration of Helsinki of 1975, as revised in 2008.

Human and Animal Rights

All procedures performed in the study were in accordance with the ethical standards of the institutional committee and with the 1964 Helsinki declaration and its later amendments.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Oda, E. High-sensitivity C-reactive protein, but not white blood cell count, independently predicted incident diabetes in a Japanese health screening population. Acta Diabetol 52, 983–990 (2015). https://doi.org/10.1007/s00592-015-0788-y

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  • DOI: https://doi.org/10.1007/s00592-015-0788-y

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