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Association between EPCs count and rate of coronary revascularization in asymptomatic type 2 diabetic patients

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Abstract

Coronary arterial disease (CAD) is common in diabetic patients, and endothelial progenitor cells (EPCs) are considered a surrogate marker for CAD, but controversies regarding this issue still remain. We investigated the potential clinical role of EPCs during coronary screening in asymptomatic type 2 diabetic patients screened with cardiovascular magnetic resonance (CMR). A total of 100 asymptomatic type 2 diabetic subjects (51 men and 49 women) were enrolled. Clinical and laboratory parameters, including EPCs (CD34+/CD133+/VEGFR-2+) count, were evaluated and CMR was performed. A total of 51 patients [silent myocardial infarction (n = 3), inducible ischemia (n = 11), suspected CAD (n = 37)] had abnormal finding on CMR. Of the 20 patients who later underwent invasive coronary angiography, 8 were treated with revascularization. Fifty-one subjects with abnormal finding on CMR were divided into two groups [subjects with revascularization (group I, n = 8) vs. without revascularization (group II, n = 43)]. Group I had a significantly increased EPCs level than group II (833 vs. 415, P = 0.027). Multivariate logistic regression analysis revealed that an increased EPCs level (OR = 1.003, P = 0.024) and a high body-mass index (OR = 1.907, P = 0.028) were independently correlated with revascularization. In our study, increased EPCs count is associated with performing revascularization in asymptomatic type 2 diabetic patients, and that increased EPCs count can provide clinically important information while performing intervention.

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Acknowledgments

This study was supported by the National Research Foundation of Korea Grant funded by the Korean Government (MEST) (NRF-2010-0003277 and NRF-2009-0064591).

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Authors and Affiliations

  1. Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Korea

    Hyun Min Kim, Kwang Joon Kim, Jae Hoon Moon, Hyuk-Jae Chang, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee & Byung-Wan Lee

  2. Department of Radiology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Korea

    Hye-Jeong Lee & Young Jin Kim

  3. Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Korea

    Min Kyung Chae

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  1. Hyun Min Kim
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Correspondence to Young Jin Kim or Byung-Wan Lee.

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592_2011_360_MOESM1_ESM.jpg

Supplemental Figure 1. Comparison of EPCs count according to glycemic control, medication, or presence of smoking history. Once HbA1c was stratified into interquartile ranges, there was a trend of decrease in EPCs count in the high HbA1c group (A). There was a trend of increase in EPCs count in patients taking statin (B), or TZD (C). EPCs count increased in patients taking ARB/ACEi (D). EPCs count decreased in patients with smoking history (E). EPCs = endothelial progenitor cells; HbA1c = glycated hemoglobin; TZD = thiazolidinedione; ARB = Angiotensin II receptor blocker; ACEi = Angiotensin-1 conversion enzyme inhibitor. Supplementary material 1 (JPEG 1146 kb)

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Kim, H.M., Kim, K.J., Moon, J.H. et al. Association between EPCs count and rate of coronary revascularization in asymptomatic type 2 diabetic patients. Acta Diabetol 49, 413–420 (2012). https://doi.org/10.1007/s00592-011-0360-3

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  • DOI: https://doi.org/10.1007/s00592-011-0360-3

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