Abstract
Relationship between serum vascular endothelial growth factor (VEGF) level and parameters of endothelial injury and/or dysfunction in patients with diabetes mellitus type 2 with or without microalbuminuria was investigated. Eighty-four diabetic patients were divided in two subgroups (42 each): normoalbuminuric (NAU) and microalbuminuric (MAU). Forty-two blood donors were in control group. Serum VEGF and plasma von Willebrand factor, soluble thrombomodulin, plasminogen activator inhibitor 1, thrombin-activatable fibrinolysis inhibitor (TAFI) and tissue plasminogen activator (t-PA) were measured using enzyme-linked immunosorbent assay in all subjects. VEGF was significantly higher in NAU compared to controls. The difference between MAU and controls was not statistically significant, but there was a trend toward significance. Only TAFI correlated with VEGF in MAU. An observed significant increase of serum VEGF level already in NAU suggests that serum VEGF could be a sensitive predictor of endothelial dysfunction in type 2 diabetes.
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The work was supported by grants VEGA 1/2309/05, 1/3381/06 and Comenius University grants 77/2007 and 421/2008. Hereby, we would like to express our thanks to Jozefína Petrovičová, MSc., PhD. from the Institute of Medical Informatics, Medical Faculty of Pavol Jozef Šafárik, University in Košice for her considerable help with the statistical evaluation of our results.
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Kubisz, P., Chudý, P., Staško, J. et al. Circulating vascular endothelial growth factor in the normo- and/or microalbuminuric patients with type 2 diabetes mellitus. Acta Diabetol 47, 119–124 (2010). https://doi.org/10.1007/s00592-009-0127-2
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DOI: https://doi.org/10.1007/s00592-009-0127-2