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Metabolic effects of time-released garlic powder tablets in type 2 diabetes mellitus: the results of double-blinded placebo-controlled study

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Abstract

Late complications in type 2 diabetic patients are commonly associated with accelerated development of atherosclerosis. In type 2 diabetes mellitus, non-enzymatic glycosylation of apo-B that is a function of hyperglycaemia is an efficient biochemical way of low-density lipoprotein atherogenic modification. So, proper metabolic control is needed to prevent late complications of diabetes. The study was performed to estimate the effects of time-released garlic powder tablet Allicor on the parameters of metabolic control and plasma lipids in type 2 diabetes mellitus. The metabolic action of Allicor was investigated in the 4-week double-blinded placebo-controlled study in 60 type 2 diabetic patients. Fasting blood glucose was measured daily, and serum fructosamine as well as cholesterol and triglyceride levels were determined at the baseline, after 1, 2, 3 and 4 weeks. It has been demonstrated that treatment with Allicor resulted in better metabolic control due to the lowering of fasting blood glucose, serum fructosamine and serum triglyceride levels. The results of this study may allow recommending garlic powder tablets Allicor for the treatment of type 2 diabetes mellitus along with dietary treatment and/or sulfonylurea derivatives to achieve better metabolic control. The benefits from garlic preparations may lead to the reduction of cardiovascular risk in diabetic patients.

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Acknowledgments

The authors thank the participants of this study for their time, effort and support. This work was supported with grant from the Institute for Atherosclerosis Research, Moscow, Russia.

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Authors and Affiliations

  1. Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia

    Igor A. Sobenin, Tatiana V. Gorchakova & Alexander N. Orekhov

  2. Russian Medical Academy of Postgraduate Education, Moscow, Russia

    Lyudmila V. Nedosugova & Mikhail I. Balabolkin

  3. Institute of Experimental Cardiology, Russian Cardiology Research Center, 15-a 3rd Cherepkovskaya Str., 121552, Moscow, Russia

    Igor A. Sobenin, Lyudmila V. Filatova & Tatiana V. Gorchakova

  4. Institute for Atherosclerosis Research, Russian Academy of Natural Sciences, Moscow, Russia

    Alexander N. Orekhov

Authors
  1. Igor A. Sobenin
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  2. Lyudmila V. Nedosugova
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  3. Lyudmila V. Filatova
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  4. Mikhail I. Balabolkin
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  5. Tatiana V. Gorchakova
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  6. Alexander N. Orekhov
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Correspondence to Tatiana V. Gorchakova.

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Sobenin, I.A., Nedosugova, L.V., Filatova, L.V. et al. Metabolic effects of time-released garlic powder tablets in type 2 diabetes mellitus: the results of double-blinded placebo-controlled study. Acta Diabetol 45, 1–6 (2008). https://doi.org/10.1007/s00592-007-0011-x

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  • DOI: https://doi.org/10.1007/s00592-007-0011-x

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