Date: 13 May 2012
The effect of omega-3 fatty-acid supplements on perioperative bleeding following posterior spinal arthrodesis
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
To investigate the effect of omega-3 fatty-acid supplements (n-3FA) on bleeding during posterior spinal arthrodesis.
We reviewed all one- or two-level posterolateral lumbar decompression/fusions with or without interbody fusion by five surgeons within 3 years. Patients taking n-3FA preoperatively were matched 1:2 with controls based on procedure, surgeon and operative time. Patients with abnormal coagulation parameters, known bleeding disorders or other medications that could affect surgical blood loss were excluded.
Twenty-eight patients met inclusion criteria. The n-3FA and control groups were similar with respect to gender, age, body mass index, operative time, and preoperative use of non-steroidal anti-inflammatory drugs. The n-3FAs were stopped an average of 5.2 days before surgery (range 1–10). Mean estimated blood loss (EBL) was 697 ml in the n-3FA group and 771 ml in the control group (p = 0.36). Mean transfused volume of Cell Saver (CS) was 282 ml in the n-3FA group and 321 ml in the control group (p = 0.30). A post hoc power analysis showed that the study was powered to detect a minimum difference of 105 ml for EBL and 50 ml for CS. The multivariate generalized estimating equation did not show a significant difference between groups for EBL or CS (p = 0.35 and p = 0.29, respectively). Secondary outcomes including drop in postoperative hemoglobin, transfusion requirement, complications and surgical drain output were similar between the two groups.
The n-3FA use did not contribute to higher perioperative blood loss during spinal arthrodesis.
An erratum to this article can be found at http://dx.doi.org/10.1007/s00586-012-2412-y.
Goodnight SH Jr, Harris WS, Connor WE (1981) The effects of dietary omega 3 fatty acids on platelet composition and function in man: a prospective, controlled study. Blood 58:880–885PubMed
Knapp HR (1997) Dietary fatty acids in human thrombosis and hemostasis. Am J Clin Nutr 65:1687S–1698SPubMed
von Schacky C, Weber PC (1985) Metabolism and effects on platelet function of the purified eicosapentaenoic and docosahexaenoic acids in humans. J Clin Invest 76:2446–2450CrossRef
Tremoli E, Maderna P, Marangoni F et al (1995) Prolonged inhibition of platelet aggregation after n-3 fatty acid ethyl ester ingestion by healthy volunteers. Am J Clin Nutr 61:607–613PubMed
Nilsen DW, Dalaker K, Nordoy A et al (1991) Influence of a concentrated ethylester compound of n-3 fatty acids on lipids, platelets and coagulation in patients undergoing coronary bypass surgery. Thromb Haemost 66:195–201PubMed
Food and Drug Administration. Dietary Supplement Guidelines. Available at: http://www.fda.gov/food/dietarysupplements/default.htm. Accessed 9 Aug 2011
Nordoy A, Hatcher L, Goodnight S, Fitzgerald GA, Conner WE (1994) Effects of dietary fat content, saturated fatty acids, and fish oil on eicosanoid production and hemostatic parameters in normal men. J Lab Clin Med 123:914–920PubMed
Food and Drug Administration. Omega-3 Fatty Acid Qualified Health Claim. Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2004/ucm108351.html. Accessed 9 Aug 2011
Kepler CK, Huang RC, Meredith DS, Kim JH, Sharma AK (2011) Omega-3 and fish oil supplements do not cause increased bleeding during spinal decompression surgery. J Spinal Disord Tech [Epub ahead of print]
- The effect of omega-3 fatty-acid supplements on perioperative bleeding following posterior spinal arthrodesis
European Spine Journal
Volume 21, Issue 12 , pp 2659-2663
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Omega-3 fatty acids
- Spinal arthrodesis
- Industry Sectors
- Author Affiliations
- 1. Department of Orthopedic Surgery, Hospital for Special Surgery, 535 E 70th ST, New York, NY, 10021, USA
- 2. Department of Orthopedic Surgery, Rothman Institute, Thomas Jefferson University, Philadelphia, PA, USA
- 3. Department of Orthopedic Surgery, University of Miami, Miami, FL, USA