Abstract
This study evaluated the systemic effects of metamizole with or without general anesthesia in healthy dogs. Twelve mixed healthy dogs of either sex were divided randomly into two groups (control and anesthesia groups). Following a 12-h period of fasting (food and water), both groups received the first dose of metamizole (35 mg/kg) intravenously and then 4 doses intramuscularly every 12 h after receiving the first dose of metamizole. In the anesthesia group, the animals underwent halothane inhalation anesthesia for 2 h after receiving the first dose of metamizole. The vital signs were monitored but animals did not receive any fluid during anesthesia. Blood samples were taken before fasting, after 12 h of fasting and then 24 and 48 h after the first dose of metamizole for evaluation of CBC, blood urea nitrogen, and serum creatinine. Mucosal bleeding times (MBTs) and bone marrow samples were evaluated prior to the start of the study and after the last dose of metamizole in both groups. The total number of red blood cells, PCV, and BUN values showed a significant increase 12 h after fasting compared with baseline values in both groups. There were no significant differences in bleeding times or bone marrow function compared to baseline in either group. It was concluded that short-term use of metamizole, starting before surgery and anesthesia in normal dogs that have not received fluids, does not have adverse effects on renal, coagulation, blood, and bone marrow functions.
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Al-Gizawiy MM, Rude E (2004) Comparison of preoperative carprofen and postoperative butorphanol as postsurgical analgesics in cats undergoing ovariohysterectomy. Vet Anaesth Analg 31:164–174
Baumgärtner CM, Koenighaus H, Ebner JK, Henke J, Schuster T, Erhardt WD (2009) Cardiovascular effects of dipyrone and propofol on hemodynamic function in rabbits. Am J Vet Res 70:1407–1415
Bergmann HM, Nolte JA, Kramer S (2005) Effects of preoperative administration of carprofen on renal function and hemostasis in dogs undergoing surgery for fracture repair. Am J Vet Res 66:1356–1363
Blois SL, Allen DG, Wood RD, Conlon PD (2010) Effects of aspirin, carprofen, deracoxib, and meloxicam on platelet function and systemic prostaglandin concentrations in healthy dogs. Am J Vet Res 71:349–358
Bostrom IM, Nyman GC, Lord PE, Häggström J, Jones BE, Bohlin HP (2002) Effects of carprofen on renal function and results of serum biochemical and hematologic analyses in anesthetized dogs that had low blood pressure during anesthesia. Am J Vet Res 63:712–721
Bostrom IM, Nyman G, Hoppe A (2006) Effects of meloxicam on renal function in dogs with hypotension during anaesthesia. Vet Anaesth Analg 33:62–69
Brainard BM, Meredith CP, Callan MB, Budsberg SC, Shofer FS, Driessen B, Otto CM (2007) Changes in platelet function, hemostasis, and prostaglandin expression after treatment with nonsteroidal anti-inflammatory drugs with various cyclooxygenase selectivities in dogs. Am J Vet Res 68:251–257
Carroll GL, Howe LB, Peterson KD (2005) Analgesic efficacy of preoperative administration of meloxicam or butorphanol in onychectomized cats. J Am Vet Med Assoc 226:913–919
Chandrasekharan NV, Dai H, Roos KL, Evanson NK, Tomsik J, Elton TS, Simmons DL (2002) Cox-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure and expression. Proc Natl Acad Sci U S A 99:13926–13931
Chohan AS, Davidow EB (2015) Clinical pharmacology and administration of fluid, electrolyte, and blood component solutions. In: Grimm KA, Lamont LA, Tranquilli WJ, Greene SA, Robertson SA (eds) Veterinary anesthesia and analgesia: the fifth edition of Lumb and Jones. John Wiley & Sons, Inc., USA, pp 386–413
Crandell DE, Mathews KA, Dyson DH (2004) Effect of meloxicam and carprofen on renal function when administered to healthy dogs prior to anesthesia and painful stimulation. Am J Vet Res 65:1384–1390
Curry SL, Cogar SM, Cook JL (2005) Nonsteroidal antiinflammatory drugs: a review. J Am Anim Hosp Assoc 41:298–309
Dahl JB, Kehlet H (1993) The value of pre-emptive analgesia in the treatment of postoperative pain. Br J Anaesth 70:434–439
Flôr PB, Yazbek KV, Ida KK, Fantoni DT (2013) Tramadol plus metamizole combined or not with anti-inflammatory drugs is clinically effective for moderate to severe chronic pain treatment in cancer patients. Vet Anaesth Analg 40:316–327
Forsyth SF, Guilford WG, Pfeiffer DU (2000) Effect of NSAID administration on creatinine clearance in healthy dogs undergoing anaesthesia and surgery. J Small Animal Pract 41:547–550
Frendin JHM, Bostrom IM, Kampa N, Eksell P, Häggström JU, Nyman GC (2006) Effects of carprofen on renal function during medetomidine-propofol-isoflurane anesthesia in dogs. Am J Vet Res 67:1967–1973
Grisneaux E, Pibarot P, Dupuis J, Blais D (1999) Comparison of ketoprofen and carprofen administered prior to orthopedic surgery for control of postoperative pain in dogs. J Am Vet Med Assoc 215:1105–1110
Haskins SC (2015) Monitoring anesthetized patients. In: Grimm KA, Lamont LA, Tranquilli WJ, Greene SA, Robertson SA (eds) Veterinary anesthesia and analgesia: the fifth edition of Lumb and Jones. John Wiley & Sons, Inc., USA, pp 86–113
Hickford FH, Barr SC, Erb HN (2001) Effect of carprofen on hemostatic variables in dogs. Am J Vet Res 62:1642–1646
Hinz B, Cheremina O, Bachmakov J, Renner B, Zolk O, Fromm MF, Brune K (2007) Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: new insights into the pharmacology of an old analgesic. FASEB J 21:2343–2351
Imagawa VH, Fantoni DT, Tatarunas AC, Mastrocinque S, Almeida TF, Ferreira F, Posso IP (2011) The use of different doses of metamizole for post-operative analgesia in dogs. Vet Anaesth Analg 38:385–393
Kalchofner Guerrero KS, Schwarz A, Wuhrmann R, Feldmann S, Hartnack S, Bettschart-Wolfensberger R (2015) Comparison of a new metamizole formulation and carprofen for extended post-operative analgesia in dogs undergoing ovariohysterectomy. Vet J 204:99–104
Ko JC, Miyabiyashi T, Mandsager RE, Heaton-Jones TG, Mauragis DF (2000) Renal effects of carprofen administered to healthy dogs anesthetized with propofol and isoflurane. J Am Vet Med Assoc 217:346–349
Lascelles BD, Cripps PJ, Jones A, Waterman-Pearson AE (1998) Efficacy and kinetics of carprofen, administered preoperatively or postoperatively, for the prevention of pain in dogs undergoing ovariohysterectomy. Vet Surg 27:568–582
Lemke KA, Runyon CL, Horney BS (2002a) Effects of preoperative administration of ketoprofen on whole blood platelet aggregation, buccal mucosal bleeding time, and hematologic indices in dogs undergoing elective ovariohysterectomy. J Am Vet Med Assoc 220:1818–1822
Lemke KA, Runyon CL, Horney BS (2002b) Effects of preoperative administration of ketoprofen on anesthetic requirements and signs of postoperative pain in dogs undergoing elective ovariohysterectomy. J Am Vet Med Assoc 221:1268–1275
Lobetti RG, Joubert KE (2000) Effect of administration of nonsteroidal anti-inflammatory drugs before surgery on renal function in clinically normal dogs. Am J Vet Res 61:1501–1507
Lorena SE, Luna SP, Lascelles BD, Corrente JE (2014) Current attitudes regarding the use of perioperative analgesics in dogs and cats by Brazilian veterinarians. Vet Anaesth Analg 41:82–89
Martins TL, Kahvegian MA, Noel-Morgan J, Leon-Roman MA, Otsuki DA, Fantoni DT (2010) Comparison of the effects of tramadol, codeine, and ketoprofen alone or in combination on postoperative pain and on concentrations of blood glucose, serum cortisol, and serum interleukin-6 in dogs undergoing maxillectomy or mandibulectomy. Am J Vet Res 71:1019–1026
Mathews KA, Pettifer G, Foster R, McDonell W (2001) Safety and efficacy of preoperative administration of meloxicam, compared with that of ketoprofen and butorphanol in dogs undergoing abdominal surgery. Am J Vet Res 62:882–888
Mullins KB, Thomason JM, Lunsford KV, Pinchuk LM, Langston VC, Wills RW, McLaughlin RM, Mackin AJ (2012) Effects of carprofen, meloxicam and deracoxib on platelet function in dogs. Vet Anaesth Analg 39:206–217
Papich MG, Messenger K (2015) Non-steroidal anti-inflammatory drugs. In: Grimm KA, Lamont LA, Tranquilli WJ, Greene SA, Robertson SA (eds) Veterinary anesthesia and analgesia: the fifth edition of Lumb and Jones. John Wiley & Sons, Inc., USA, pp 227–243
Schug SA, Manopas A (2007) Update on the role of non-opioids for postoperative pain treatment. Best Pract Res Clin Anaesthesiol 21:15–30
Slingsby LS, Waterman-Pearson AE (2002) Comparison between meloxicam and carprofen for postoperative analgesia after feline ovariohysterectomy. J Small Anim Pract 43:286–289
Teixeira RC, Monteiro ER, Campagnol D, Coelho K, Bressan TF, Monteiro BS (2013) Effects of tramadol alone, in combination with meloxicam or dipyrone, on postoperative pain and the analgesic requirement in dogs undergoing unilateral mastectomy with or without ovariohysterectomy. Vet Anaesth Analg 40:641–649
Williams VM, Lascelles BDX, Robson MC (2005) Current attitudes to, and use of, peri-operative analgesia in dogs and cats by veterinarians in New Zealand. N Z Vet J 53:193–202
Wolfle T (2000) Understanding the role of stress in animal welfare: practical considerations. In: Moberg GP and Mench JA (eds) Biology of animal stress: the basic principles and implications for animal welfare. CAB International, New York, pp 355–368
Zanuzzo FS, Teixeira-Neto FJ, Teixeira LR, Diniz MS, Souza VL, Thomazini CM, Steagall PV (2015) Analgesic and antihyperalgesic effects of dipyrone, meloxicam or a dipyrone–meloxicam combination in bitches undergoing ovariohysterectomy. Vet J 205:33–37
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This work was supported by grant No. 88-GR-VT-29 from the Research Council of Shiraz University.
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Sarchahi, A., Vesal, N., Khalighi, F. et al. Effects of preanesthetic administration of metamizole on renal function, blood parameters and bone marrow cells in healthy dogs. Comp Clin Pathol 26, 657–662 (2017). https://doi.org/10.1007/s00580-017-2437-z
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DOI: https://doi.org/10.1007/s00580-017-2437-z