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Prevalence of hepatitis B, hepatitis C, and human immunodeficiency virus infections among hemophilia patients in Shiraz, south of Iran

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Abstract

Transfusion-transmitted viral infections, including hepatitis B (HBV), hepatitis C (HCV), and human immunodeficiency virus (HIV) infections continue to be a major challenge in hemophilia patient. This study was conducted to assess the seroprevalence of HBV, HCV, and HIV infections among Iranian hemophilia patients. A cross-sectional study was conducted on 580 hemophilia patients (mean age ± SD = 27.11 ± 14.9) referred to the Namazi hospital, Shiraz University of medical sciences, Shiraz, Iran during July 2012 to August 2015. Blood samples were taken from the patients and tested for HBV surface antigen (HBsAg), antibody to HBV surface antigen (anti-HBs), antibody to HBV core antigen (anti-HBc), anti-HCV antibody (HCVAb), and anti-HIV antibody (HIVAb). The association of HBV, HCV, and HIV infections with age, sex, type of hemophilia (A or B), severity of hemophilia, blood group system, history of blood transfusion, and surgery were statistically analyzed using SPSS software and chi-square/Fisher exact tests. The seroprevalence of HCVAb and HBsAg were 11.4 % (66/580) and 0.2 % (1/580), respectively. None of the hemophilia patients were positive for HIV antibody. There was a significant association between HCV seropositivity and age (P < 0.001), severity of hemophilia (P < 0.0001), and history of blood transfusion (P = 0.050). It seems that strategies for prevention of HBV and HIV infections have been successful in south of Iran, but HCV is still a major infection of concern in multi-transfused patients.

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Authors and Affiliations

  1. Research Center for NonCommunicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran

    Saeed Mohammadi Nezhad, Mohammad Sadegh Sanie & Hassan Ali Abedi

  2. Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

    Atefeh Esmailnejad & Homa Niknam

Authors
  1. Saeed Mohammadi Nezhad
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  2. Atefeh Esmailnejad
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  3. Mohammad Sadegh Sanie
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  4. Hassan Ali Abedi
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  5. Homa Niknam
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Correspondence to Atefeh Esmailnejad.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the Shiraz University of medical sciences committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Nezhad, S.M., Esmailnejad, A., Sanie, M.S. et al. Prevalence of hepatitis B, hepatitis C, and human immunodeficiency virus infections among hemophilia patients in Shiraz, south of Iran. Comp Clin Pathol 25, 953–957 (2016). https://doi.org/10.1007/s00580-016-2286-1

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  • DOI: https://doi.org/10.1007/s00580-016-2286-1

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