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A case of chronic lymphoblastic leukemia with an abnormal rare karyotype

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Abstract

Chronic lymphoid leukemia (CLL) is a lymphoproliferative disorder with clonal proliferation and accumulation of mature B-cells in BM, peripheral blood, and secondary lymphoid organs. Most patients show del(13q), del(11q), +12, del(17p), and del(6q) genetic abnormalities, and chromosomal translocation has been rarely reported in them. We report a 43-year-old man diagnosed with CLL with two additional marker chromosome segments of unknown origin 48, XY, +mar, +mar analyzed by G-banded karyotype analysis. Peripheral blood smear revealed markedly increased white blood cell count (WBC, 84,000/mm3) with predominance of lymphoid cells with dense chromatin. To our knowledge, this chromosomal abnormality in CLL has not been previously described, and we report it for the first time from Iran.

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References

  • Cerny J, Yu H, Miron PM (2013) Novel FGFR3 rearrangement t (4; 22)(p16; q11. 2) in a patient with chronic lymphocytic leukemia/small lymphocytic lymphoma. Ann Hematol 92(10):1433–1435

    Article  PubMed  Google Scholar 

  • Conchon M, McManus AP, Min T, Maljaie SH, Crawford A, Brito-Babapulle V et al (1997) Two unbalanced translocations, t (12; 22)(p13; q11) and t (12;?)(p13;?), in an aggressive chronic B-cell leukemia: TEL gene analysis using FISH. Cancer Genet Cytogenet 95(2):137–140

    Article  CAS  PubMed  Google Scholar 

  • Crisostomo RH, Fernandez JA, Caceres W (2007) Complex karyotype including chromosomal translocation (8; 14)(q24; q32) in one case with B-cell prolymphocytic leukemia. Leuk Res 31(5):699–701

    Article  CAS  PubMed  Google Scholar 

  • de Oliveira FM, Brandao RA, Leite-Cueva SD, de Paula CF, Simoes BP, Rego EM et al (2010) Tetrasomy 8 in a patient with chronic lymphocytic leukemia. Cancer Genet Cytogenet 198(2):166–169

    Article  PubMed  Google Scholar 

  • Döhner H, Stilgenbauer S, Benner A, Leupolt E, Kröber A, Bullinger L et al (2000) Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 343(26):1910–1916

    Article  PubMed  Google Scholar 

  • Dyer M, Oscier D (2002) The configuration of the immunoglobin genes in B cell chronic lymphocytic leukemia. Leuk (08876924) 16(6)

  • Eclache V, Benzacken B, Kettaneh A, Fain O (eds) (2002) A constitutional translocation t (1; 4)(p21; p15) in a case of chronic lymphocytic leukemia. Annales de genetique. Elsevier Masson

  • Espinet B, Salido M, Hernández JÁ, Zamora L, Bosch MA, Serrano S et al (2003) Cytogenetic findings in familial B-cell chronic lymphocytic leukemia: a report of two cases in a family. Cancer Genet Cytogenet 143(2):172–173

    Article  CAS  PubMed  Google Scholar 

  • Hallek M (2013) Chronic lymphocytic leukemia: 2013 update on diagnosis, risk stratification and treatment. Am J Hematol 88(9):803–816

    Article  CAS  PubMed  Google Scholar 

  • Herholz H, Kern W, Schnittger S, Haferlach T, Dicker F, Haferlach C (2007) Translocations as a mechanism for homozygous deletion of 13q14 and loss of the < i > ATM</i > gene in a patient with B-cell chronic lymphocytic leukemia. Cancer Genet Cytogenet 174(1):57–60

    Article  CAS  PubMed  Google Scholar 

  • Hsiao H-H, Hung Y-H, Hsiao H-P, Tseng S-B, Tsai H-J, Liu Y-C et al (2004) Case of chronic lymphocytic leukemia with unusual chromosome aberrations. Int J Hematol 80(4):351–353

    Article  PubMed  Google Scholar 

  • Karakosta M, Voulgarelis M, Vlachadami I, Manola KN (2010a) Translocation (6; 13)(p21; q14. 1) as a rare nonrandom cytogenetic abnormality in chronic lymphocytic leukemia. Cancer Genet Cytogenet 198(1):66–70

    Article  CAS  PubMed  Google Scholar 

  • Karakosta M, Tsakiridou A, Korantzis I, Manola KN (2010b) Deletion of 5q as a rare abnormality in chronic lymphocytic leukemia. Cancer Genet Cytogenet 200(2):175–179

    Article  CAS  PubMed  Google Scholar 

  • Kiefer Y, Drieschner N, Förster H, Tiemann M, Schulte C, Rommel B et al (2010) An unbalanced t (15; 18)(q21-q22; p11) as the sole cytogenetic aberration in a patient with B-cell chronic lymphocytic leukemia. Cancer Genet Cytogenet 200(1):65–69

    Article  CAS  PubMed  Google Scholar 

  • Kiefer Y, Schulte C, Tiemann M, Bullerdiek J (2012) Chronic lymphocytic leukemia-associated chromosomal abnormalities and miRNA deregulation. Appl Clin Genet 5:21

    PubMed Central  CAS  PubMed  Google Scholar 

  • Sagatys EM, Zhang L (2012) Clinical and laboratory prognostic indicators in chronic lymphocytic leukemia. Cancer Control: J Moffitt Cancer Cent 19(1):18–25

    Google Scholar 

  • Schmidt HH, Dyomin VG, Palanisamy N, Itoyama T, Nanjangud G, Pirc-Danoewinata H et al (2004) Deregulation of the carbohydrate (chondroitin 4) sulfotransferase 11 (CHST11) gene in a B-cell chronic lymphocytic leukemia with at (12; 14)(q23; q32). Oncogene 23(41):6991–6996

    Article  CAS  PubMed  Google Scholar 

  • Sen F, Lai R, Albitar M (2002) Chronic lymphocytic leukemia with t (14; 18) and trisomy 12: report of 2 cases and review of the literature. Arch Pathol Lab Med 126(12):1543–1546

    PubMed  Google Scholar 

  • Shaffer LG, Marilyn L, Slovak, Campbell LJ. ISCN (2009) An International System for Human Cytogenetic Nomenclature

  • Smolewski P, Witkowska M, Korycka-Wolowiec A (2013) New insights into biology, prognostic factors, and current therapeutic strategies in chronic lymphocytic leukemia. ISRN Oncol 2013:740615

    PubMed Central  PubMed  Google Scholar 

  • Vroblova V, Smolej L, Vrbacky F, Jankovicova K, Hrudkova M, Maly J et al (2009) Biological prognostic markers in chronic lymphocytic leukemia. Acta Med 52(1):3–8

    CAS  Google Scholar 

  • Wang H-Y, Tirado CA (2010) < i> t</i>(8; 21)(q22; q22) Translocation involving AML1 and ETO in B lymophoblastic leukemia. Hum Pathol 41(2):286–292

    Article  CAS  PubMed  Google Scholar 

  • Wong K (2002) Chronic lymphocytic leukemia with a novel der (8; 15)(q10; q10) translocation. Cancer Genet Cytogenet 132(2):159–160

    Article  CAS  PubMed  Google Scholar 

  • Xu W, Cao X, Liu Q, Fan L, Miao K-R, Qiu H-R et al (2009) Trisomy 8 in two newly diagnosed Chinese patients with chronic lymphocytic leukemia. Cancer Genet Cytogenet 192(2):79–81

    Article  CAS  PubMed  Google Scholar 

  • Zanette DL, Rivadavia F, Molfetta GA, Barbuzano FG, Proto-Siqueira R, Silva-Jr WA et al (2007) miRNA expression profiles in chronic lymphocytic and acute lymphocytic leukemia. Braz J Med Biol Res = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica [et al] 40(11):1435–1440

    CAS  Google Scholar 

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Acknowledgments

We wish to thank all our colleagues in Noor Clinical & Specialty Laboratory, Ahvaz, Iran.

Authors’ contributions

Javad mohammdai-asl and Najmaldin Saki contributed to the conception and design of the study. NedaGolchin and Mohammad-hosein Masbi contributed to the provision of study materials or patients. Saeideh Hajizamani and Javad mohammdai-asl contributed to the collection and assembly of data. Ahmad Ahmadzadeh and Javad mohammdai-asl contributed to the data analysis and interpretation. Najmaldin Saki, Saeideh Hajizamani and Mohammad Shahjahani contributed to the manuscript writing. All authors to the final approval of manuscript.

Conflicts of interest

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Medical Genetics, Ahvaz Jundishapur University of Medical sciences, Ahvaz, Iran

    Javad Mohammdai-asl

  2. Health Research Institute, Research Center of Thalassemia and Hemoglobinopathy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Saeideh Hajizamani, Mohammad Shahjahani, Ahmad Ahmadzadeh & Najmaldin Saki

  3. Noor Clinical & Specialty Laboratory, Ahvaz, Iran

    Neda Golchin & Mohammad-hosein Masbi

Authors
  1. Javad Mohammdai-asl
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  2. Saeideh Hajizamani
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  3. Mohammad Shahjahani
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  4. Neda Golchin
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  5. Mohammad-hosein Masbi
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  6. Ahmad Ahmadzadeh
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  7. Najmaldin Saki
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Correspondence to Najmaldin Saki.

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Mohammdai-asl, J., Hajizamani, S., Shahjahani, M. et al. A case of chronic lymphoblastic leukemia with an abnormal rare karyotype. Comp Clin Pathol 24, 1117–1121 (2015). https://doi.org/10.1007/s00580-014-2044-1

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  • DOI: https://doi.org/10.1007/s00580-014-2044-1

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