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Clinicopathological and immunohistochemical characteristics of ovarian luteoma associated with endometrial hyperplasia in a bitch

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Abstract

In the present study, a rare case of ovarian luteoma is described in a 5-year-old German Shepherd dog. Histopathologically, the tissue sections composed of multiple lobules of polyhedral cells with abundant, finely vacuolated cytoplasm, centrally located nuclei surrounded by fine well-vascularized connective tissue. Neoplastic cells showed strong cytoplasmic positivity for inhibin-α and vimentin and moderate for calretinin. Based on histopathological and immunohistochemical findings, the tumor was diagnosed as ovarian luteoma.

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References

  • Choi US, Seo KW, Oh SY, Kim DY, Youn HY, Lee CW (2005) Intra-abdominal mass aspirate from a cat in heat. Vet Clin Pathol 34:275–277

    Article  PubMed  Google Scholar 

  • Christman SA, Bailey MT, Wheaton JE, Troedsson MH, Ababneh MM, Santschi EM (1999) Dimeric inhibin concentrations in mares with granulosa-theca cell tumors. Am J Vet Res 60:1407–1410

    CAS  PubMed  Google Scholar 

  • Costa MJ, Ames PF, Walls J, Roth LM (1997) Inhibin immunohistochemistry applied to ovarian neoplasms: a novel, effective diagnostic tool. Hum Pathol 28:1247–1254

    Article  CAS  PubMed  Google Scholar 

  • Cotchin E (1961) Canine ovarian neoplasma. Res Vet Sci 2:133–142

    Google Scholar 

  • Doglioni C, Dei Tos AP, Laurino L (1996) Calretinin: a novel immunocytochemical marker for mesothelioma. Am J Surg Pathol 20:1037–1046

    Article  CAS  PubMed  Google Scholar 

  • Hayes A, Harvey HJ (1979) Treatment of metastatic granulosa cell tumor in a dog. J Am Vet Med Assoc 174:1304–1306

    CAS  PubMed  Google Scholar 

  • Ichimura R, Shibutani I, Mizukami S, Suzuki T, Shimada Y, Mitsumori K (2010) A case report of an uncommon sex-cord stromal tumor consisting of luteal and Sertoli cells in a spayed bitch. J Vet Med Sci 72(2):229–234

    Article  PubMed  Google Scholar 

  • Jubb KVF, Kennedy PC, Palmer N (2007) Pathology of domestic animals, 5th ed, vol 3. Academic, New York

    Google Scholar 

  • Kennedy PC, Miller RB (1993) The female genital system. In: Jubb KVF, Kennedy PC, Palmer N (eds) Pathology of domestic animals, 4th edn. Academic, San Diego, pp 349–470

    Chapter  Google Scholar 

  • Marino G, Nicòtina PA, Catone G, Bontempo RA, Zanghì A (2003) Alpha-inhibin expression in canine ovarian neoplasms: preliminary results. Vet Res Commun 27:237–240

    Article  PubMed  Google Scholar 

  • Mcentee K (1990) Ovarian neoplasms. In: Reproductive Pathology of Domestic Animals, Academic Press Inc, San Diego, pp69-93

  • Nagarajan P, Venkatesan R, Kumar MJ, Majumdar SS (2005) Granulosa theca cell tumor with luteoma in the ovary of a bonnet monkey (Macaca radiata). J Med Primatol 34:219–223

    Article  CAS  PubMed  Google Scholar 

  • Rishi M, Howard LN, Bratthauer GL, Tavassoli FA (1997) Use of monoclonal antibody against human inhibin as a marker for sex cord-stromal tumors of the ovary. Am J Surg Pathol 21(5):583–589

    Article  CAS  PubMed  Google Scholar 

  • Sapierzynski R, Malicka E, Bielecki W, Krawiec M, Osinska B, Sendecka H, Sobczak-filipiak M (1994) Tumors of the urogenital system in dogs and cats. Retrospective review of 138 cases. Pol J Vet Sci 10:97–103

    Google Scholar 

  • Yamini B, Vandenbrink PL, Refsal KR (1997) Ovarian steroid cell tumor resembling luteoma associated with hyperadrenocorticism (Cushing’s disease) in a dog. Vet Pathol 34:57–60

    Article  CAS  PubMed  Google Scholar 

  • Yotov S, Simeonov R, Dimitrov F, Vassilev N, Dimitrov M, Georgiev P (2005) Papillary ovarian cystadenocarcinoma in a dog. J S Afr Vet Assoc 76:43–45

    Article  CAS  PubMed  Google Scholar 

  • Young RH (2005) Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems. Mod Pathol 18:S81–S98

    Article  PubMed  Google Scholar 

Download references

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Correspondence to Fatemeh Namazi.

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Namazi, F., Abbaszadeh Hasiri, M., Nikahval, B. et al. Clinicopathological and immunohistochemical characteristics of ovarian luteoma associated with endometrial hyperplasia in a bitch. Comp Clin Pathol 24, 705–707 (2015). https://doi.org/10.1007/s00580-014-2043-2

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  • DOI: https://doi.org/10.1007/s00580-014-2043-2

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