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Contribution of HLA-DR to polycystic kidney disease in a sample of Egyptian patients

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Abstract

The aim of this study was to investigate whether certain DR alleles might contribute to the genetic susceptibility among adult polycystic kidney disease patients in Egypt. This case–control study involved human leukocyte antigen (HLA)-DR typing for 40 non-related Egyptian patients with autosomal dominant polycystic kidney disease. Patients were compared with a group of 50 healthy subjects. Human leukocyte antigen DRB1 typing was carried out on allele level (DRB1*01 — DRB1*16) using polymerase chain reaction-sequence-specific oligonucleotide probes (PCR-SSOP). No statistically significant association of the disease with HLA-DRB1 was observed. So, HLA-DRB1 does not contribute to polycystic kidney disease in Egyptian patients.

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The authors have no financial or proprietary interest in any product mentioned in this paper.

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This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Clinical Pathology, Kasr Al Ainy Hospital, Faculty of Medicine, Cairo University, Cairo, 11431, Egypt

    Rasha Mohamad Hosny Shahin

  2. Department of Urology, Kasr Al Ainy Hospital, Faculty of Medicine, Cairo University, Cairo, Egypt

    Ahmed Mahmoud Ahmed Shouman

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  1. Rasha Mohamad Hosny Shahin
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  2. Ahmed Mahmoud Ahmed Shouman
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Correspondence to Rasha Mohamad Hosny Shahin.

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Shahin, R.M.H., Shouman, A.M.A. Contribution of HLA-DR to polycystic kidney disease in a sample of Egyptian patients. Comp Clin Pathol 24, 423–426 (2015). https://doi.org/10.1007/s00580-014-1919-5

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  • DOI: https://doi.org/10.1007/s00580-014-1919-5

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