Journal of Gastroenterology

, 46:974

Hepatitis B virus X gene and hepatocarcinogenesis


    • Faculty of MedicineUniversity of New South Wales
    • Division of Medical SciencesNational Cancer Center
  • Caroline Lee
    • Department of BiochemistryNational University of Singapore
    • Division of Medical SciencesNational Cancer Center
    • Duke-NUS Graduate Medical School

DOI: 10.1007/s00535-011-0415-9

Cite this article as:
Ng, S. & Lee, C. J Gastroenterol (2011) 46: 974. doi:10.1007/s00535-011-0415-9


Chronic hepatitis B virus (HBV) infection has been identified as a major risk factor in hepatocellular carcinoma (HCC), which is one of the most common cancers worldwide. The pathogenesis of HBV-mediated hepatocarcinogenesis is, however, incompletely understood. Evidence suggests that the HBV X protein (HBx) plays a crucial role in HCC development. HBx is a multifunctional regulator that modulates transcription, signal transduction, cell cycle progression, apoptosis, protein degradation pathways, and genetic stability through interaction with host factors. This review describes the current state of knowledge of the molecular pathogenesis of HBV-induced HCC, with a focus on the role of HBx in hepatocarcinogenesis.


Hepatitis B virus HBx Hepatocellualar carcinoma Hepatocarcinogenesis

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© Springer 2011