International Forum 2

Journal of Gastroenterology

, Volume 44, Issue 19, pp 89-95

Hepatocellular carcinoma in patients with nonalcoholic steatohepatitis

  • Etsuko HashimotoAffiliated withDepartment of Internal Medicine and Gastroenterology, Tokyo Women’s Medical University
  • , Satoru YatsujiAffiliated withDepartment of Internal Medicine and Gastroenterology, Tokyo Women’s Medical University
  • , Maki TobariAffiliated withDepartment of Internal Medicine and Gastroenterology, Tokyo Women’s Medical University
  • , Makiko TaniaiAffiliated withDepartment of Internal Medicine and Gastroenterology, Tokyo Women’s Medical University
  • , Nobuyuki ToriiAffiliated withDepartment of Internal Medicine and Gastroenterology, Tokyo Women’s Medical University
  • , Katsutoshi TokushigeAffiliated withDepartment of Internal Medicine and Gastroenterology, Tokyo Women’s Medical University
  • , Keiko ShiratoriAffiliated withDepartment of Internal Medicine and Gastroenterology, Tokyo Women’s Medical University

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Abstract

Background

There have been few reports on hepatocellular carcinoma (HCC) in nonalcoholic steatohepatitis (NASH) and the natural history of NASH. Accordingly, we assessed the clinical features of HCC in NASH, the risk factors for HCC, and natural history of NASH with advanced fibrosis.

Patients and methods

There were 34 NASH patients with HCC and 348 NASH patients without HCC. To clarify the clinical features of NASH patients with HCC and to determine the risk factors for HCC, we compared NASH patients with HCC with those without HCC. Univariate and multivariate logistic regression models were used for statistical analysis. A prospective cohort study of the outcomes of 137 NASH with advanced fibrosis was started in 1990. The impact of baseline risk factors on the development of HCC and survival was evaluated by Cox regression analysis.

Results

In total, 88% of patients with HCC had advanced fibrosis, with a median age of 70 years. Older age, low level of AST, low grade of histological activity, and advanced stage of fibrosis were risk factors for HCC. A prospective cohort study showed that the 5-year cumulative incidence of HCC was 7.6%, and the 5-year survival rate was 82.8%. HCC was the leading cause of death.

Conclusions

The present study confirmed that older age and advanced fibrosis were important risk factors for HCC, and that HCC was the major cause of mortality in NASH patients with advanced fibrosis. Regular screening for HCC is thus extremely important for NASH patients with advanced fibrosis.

Key words

nonalcoholic steatohepatitis (NASH) hepatocellular carcinoma (HCC) cirrhosis