Supportive Care in Cancer

, Volume 8, Issue 3, pp 175–179

The symptoms of advanced cancer: relationship to age, gender, and performance status in 1,000 patients

  • D. Walsh
  • S. Donnelly
  • L. Rybicki
SPEZIAL ARTICLE

DOI: 10.1007/s005200050281

Cite this article as:
Walsh, D., Donnelly, S. & Rybicki, L. Support Care Cancer (2000) 8: 175. doi:10.1007/s005200050281

Abstract

 A multivariate analysis of the data was conducted to evaluate the effects of age, gender, and performance status on symptom profile. A comprehensive prospective analysis of symptoms was conducted in 1,000 patients on initial referral to the Palliative Medicine Program of the Cleveland Clinic. The median number of symptoms per patient was 11 (range 1–27). The ten most prevalent symptoms were pain, easy fatigue, weakness, anorexia, lack of energy, dry mouth, constipation, early satiety, dyspnea, and greater than 10% weight loss. The prevalence of these 10 symptoms ranged from 50% to 84%. Younger age was associated with 11 symptoms: blackout, vomiting, pain, nausea, headache, sedation, bloating, sleep problems, anxiety, depression, and constipation. Gender was associated with 8 symptoms. Males had more dysphagia, hoarseness, >10% weight loss and sleep problems; females, more early satiety, nausea, vomiting, and anxiety. Performance status was associated with 14 symptoms. Advanced cancer patients are polysymptomatic. Ten symptoms are highly prevalent. Symptom prevalence for 24 individual symptoms differs with age, or gender, or performance status.

Key words SymptomsCancerAgeGenderPerformance status

Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • D. Walsh
    • 1
  • S. Donnelly
    • 1
  • L. Rybicki
    • 2
  1. 1.Palliative Medicine Program, Department Of Hematology-Oncology, Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, USAUS
  2. 2.Department of Biostatistics and Epidemiology, Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, USAUS
  3. 3.Harry R. Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue M-76, Cleveland, OH 44195, USA e-mail: walsht@ccf.org Tel.: +1-216-4447794 Fax: +1-216-4455090 www.clevelandclinic.org/palliativeUS