Abstract
Purpose
To describe patient- and practice-related factors that physicians report affect their clinical decision to administer prophylactic pegfilgrastim to patients <24 h after completion of a myelosuppressive chemotherapy cycle (i.e., “same-day” pegfilgrastim).
Methods
Oncologists, hematologists, and hematologist-oncologists enrolled in a US national physician panel were invited to participate in a cross-sectional, web-based survey to assess physicians’ reasons for prescribing “same-day” pegfilgrastim. Physicians were screened as eligible if they reported prescribing “same-day” pegfilgrastim within the previous 6 months. The survey assessed physician perspectives and physician-perceived patient/caregiver preferences.
Results
Of 17,478 invited physicians, 386 answered the screening questions; 151 (39.1 %) were eligible, agreed to participate, and completed the survey. Physicians estimated that overall 41.3 % of their patients treated with myelosuppressive chemotherapy received pegfilgrastim and that 31.6 % treated with pegfilgrastim received it on a “same-day” schedule. Approximately 36 % of physicians relied primarily on their clinical judgment when deciding to administer “same-day” pegfilgrastim. The clinical consideration reported most commonly by physicians as moderately or very important when deciding to administer “same-day” pegfilgrastim was previous febrile neutropenia (77.6 %). The most important patient-related consideration in the decision to administer “same-day” pegfilgrastim was patient/caregiver travel distance, and the most important practice-related consideration was the burden to the physician’s practice of “next-day” administration (vs. same-day), reported by 84.7 % and 65.1 % of physicians as moderately or very important, respectively.
Conclusions
While clinical judgment, patients’ risk factors, and practice burden were principal influences favoring “same-day” pegfilgrastim administration, physician-perceived patient preferences and logistical barriers also have important roles in this decision.
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References
National Comprehensive Cancer Network (NCCN). Guidelines on myeloid growth factors, version 1. 2015. http://www.nccn.org/professionals/physician_gls/pdf/myeloid_growth.pdf. Accessed 1 September 2015
Culakova E, Thota R, Poniewierski MS, Kuderer NM, Wogu AF, Dale DC, et al. (2014) Patterns of chemotherapy-associated toxicity and supportive care in US oncology practice: a nationwide prospective cohort study. Cancer Med 3:434–444
Crawford J, Dale DC, Kuderer NM, Culakova E, Poniewierski MS, Wolff D, et al. (2008 Feb) Risk and timing of neutropenic events in adult cancer patients receiving chemotherapy: the results of a prospective nationwide study of oncology practice. J Natl Compr Cancer Netw 6(2):109–118
Kosaka Y, Ray Y, Masuda N, Takano T, Saeki T, Nakamura S, et al. (2015) Phase III placebo-controlled, double-blind, randomized trial of pegfilgrastim to reduce the risk of febrile neutropenia in breast cancer patients receiving docetaxel/cyclophosphamide chemotherapy. Support Care Cancer 23(4):1137–1143
de Naurois J, Novitzky-Basso I, Gill MJ, Marti Marti F, Cullen MH, Roila F (2010) Management of febrile neutropenia: ESMO clinical practice guidelines. Ann Oncol 21((Supplement 5)):v252–v256
Weycker D, Li X, Edelsberg J, Barron R, Kartashov A, Xu H, et al. (2015) Risk and consequences of chemotherapy-induced febrile neutropenia in patients with metastatic solid tumors. J Oncol Pract 10:47–54
Bennett CL, Calhoun EA (2007) Evaluating the total costs of chemotherapy-induced febrile neutropenia: results form a pilot study with community oncology cancer patients. Oncologist 12:478–483
Neulasta (pegfilgrastim). http://www.accessdata.fda.gov/drugsatfda_docs/label/2007/125031s082lbl.pdf. Accessed 1 Oct 2015
Smith TJ, Bohlke K, Lyman GH, Carson KR, Crawford J, Cross SJ, et al. (2015) Recommendations for the use of WBC growth factors: American Society of Clinical Oncology Clinical Practice Guideline update. J Clin Oncol 33:1–16
Weycker D, Wu H, Hagiwara M, Li X, Barron RL (2014) Use of chemotherapy and same-day pegfilgrastim prophylaxis in US clinical practice. Blood Journal 124(21):4825
Burris HA, Belani CP, Kaufman PA, Gordon AN, Schwartzberg LS, Paroly WS, et al. (2010) Pegfilgrastim on the same day versus next day of chemotherapy in patients with breast cancer, non-small-cell lung cancer, ovarian cancer, and non-Hodgkin’s lymphoma: results of four multicenter, double-blind, randomized phase II studies. J Oncol Pract 6:133–140
Skarlos DV, Timotheadou E, Galani E, Samantas E, Grimani I, Lianos E, et al. (2009) Pegfilgrastim administered on the same day with dose-dense adjuvant chemotherapy for breast cancer is associated with a higher incidence of febrile neutropenia as compared to conventional growth factor support: matched case-control study of the Hellenic Cooperative Oncology Group. Oncologia 77:107–112
Cheng C, Gallagher EM, Yeh JY, Earl MA (2014 Apr 16) Rates of febrile neutropenia with pegfilgrastim on same day versus next day of CHOP with or without rituximab. Anti-Cancer Drugs 2014[Epub ahead of print]
Saven A, Schwartzberg L, Kaywin P, Bartlett N, Dean L, Shahin S, et al (2006) Randomized, double-blind, phase 2, study evaluating same-day vs next-day administration of pegfilgrastim with R-CHOP in non-Hodgkin’s lymphoma patients. J Clin Oncol 24(suppl). [Abstract 7570]
Kaufman PA, Paroly W, Rinaldi D (2004) Randomized double blind phase 2 study evaluating same-day vs. next-day administration of pegfilgrastim with docetaxel, doxorubicin and cyclophosphamide (TAC) in women with early stage and advanced breast cancer. San Antonio Breast Cancer Symposium. Breast Cancer Res Treat 88[Abstract 1054]
Lokich JJ (2006) Same day pegfilgrastim and CHOP chemotherapy for non-Hodgkin lymphoma. Am J Clin Oncol 29:361–363
Belani CP, Ramalingam S, Al-Janadi A, Eskander E, Ghazal H, Schwartzberg L, et al (2006) A randomized double-blind phase II study to evaluate “same-day” vs next-day administration of pegfilgrastim with carboplatin and docetaxel in patients with NSCLC. J Clin Oncol 24 (suppl):abstract 7110
Schuman SI, Lambrou N, Robson K, Glück S, Myriounis N, Perarson JM, et al. (2009) Pegfilgrastim dosing on same day as myelosuppressive chemotherapy for ovarian or primary peritoneal cancer. J Support Oncol 7:225–228
Whitworth JM, Matthews KS, Shipman KA, Numnum TM, Kendrick JE, Kilgore LC, et al. (2009) The safety and efficacy of day 1 versus day 2 administration of pegfilgrastim in patients receiving myelosuppressive chemotherapy for gynecologic malignancies. Gynecol Oncol 112:601–604
Billingsley CC, Jacobson SN, Crafton SM, Crim AK, Li Q, Hade EM, et al. (2015) Evaluation of the hematologic safety of same day versus standard administration (24- to 72-hour delay) of pegfilgrastim in gynecology oncology patients undergoing cytotoxic chemotherapy. Int J Gynecol Cancer 25:1331–1336
National Comprehensive Cancer Network NCCN. Clinical Practice Guidelines in Oncology (NCCN) Guidelines®: myeloid growth factors, version 1.2015. http://www.nccn.org/professionals/physician_gls/pdf/myeloid_growth.pdf. Accessed 30 September 2015
Weycker D, Wu H, Hagiwara M, Li X, Barron RL (2014) Use of chemotherapy and same-day pegfilgrastim prophylaxis in US clinical practice. Poster presented at the American Society of Hematology Annual Meeting; December 6–9, 2014. San Francisco, CA
Fowler FJ (2014) Survey research methods. Sage, Thousand Oaks, California
Willis GB (2005) Cognitive interviewing: a tool for improving questionnaire design. Sage, Thousand Oaks, California
Patton M (1990) Qualitative evaluation and research methods, second edn. Sage, Thousand Oaks, California
European Medicines Agency. Neulasta 6 mg solution for injection. Summary of product characteristics. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000420/WC500025945.pdf. Accessed 2 Oct 2015
Acknowledgments
The authors take full responsibility for the content of the paper. Ms. Marion was an employee of RTI Health Solutions during the time the study was conducted. The authors thank Kimberly Davis, MS and Kelly Hollis, MBA (RTI Health Solutions) for their assistance. The authors wish to extend a special thanks to Allen Mangel, MD, PhD (RTI Health Solutions), for provision of technical and scientific guidance while developing the manuscript.
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Amgen, Inc.
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Marion, S., Tzivelekis, S., Darden, C. et al. “Same-Day” administration of pegfilgrastim following myelosuppressive chemotherapy: clinical practice and provider rationale. Support Care Cancer 24, 3889–3896 (2016). https://doi.org/10.1007/s00520-016-3193-3
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DOI: https://doi.org/10.1007/s00520-016-3193-3