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Venous thromboembolism risk factors in Chinese non-small cell lung cancer patients

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Abstract

Purpose

Certain clinicopathological factors contribute to the development of venous thromboembolism (VTE) in lung cancer. The aim of the current study was to assess the incidence of and the potential risk factors associated with the development of VTE in Chinese lung cancer patients.

Methods

Patients with lung cancer in our center were screened for VTE from January 2004 to July 2013. One VTE case was matched with two controls according to gender, pathology, clinical stage, and anticancer therapy.

Results

Among the 4,726 patient records screened, 61 (1.3 %) VTE cases with non-small cell lung cancer (NSCLC) were identified, including 58 (95.1 %) with adenocarcinoma and 59 (96.7 %) with advanced stage tumors (IIIb and IV). Serous effusion (OR 2.089, 95 % CI 1.022–4.270, P = 0.043), fever (OR 8.999, 95 % CI 1.688–47.968, P = 0.010), increased leukocytes (OR 4.136, 95 % CI 1.957–8.738, P < 0.001), hyponatremia (<130 mmol/L, OR 5.335, 95 % CI 1.366–20.833, P = 0.016), and increased alanine aminotransferase (ALT) (OR 3.879, 95 % CI 1.514–9.936, P = 0.005) were associated with an increased risk of VTE. Patients with poor performance status (PS) (≥2 vs. <1) (HR 1.574, 95 % CI 1.112–2.228, P = 0.010) and serous effusion (HR 1.571, 95% CI 1.114–2.215, P = 0.010) tended to have a poor prognosis. There was no difference in overall survival between VTE (median 15.2 months, 95 % CI 11.6–18.9) and control patients (median 16.3 months, 95 % CI 14.1–18.4, P = 0.184; HR 1.273, 95 % CI 0.890–1.820, P = 0.185).

Conclusions

Clinical characteristics such as serous effusion, fever, increased leukocytes, hyponatremia, and increased ALT are potential risk factors for VTE in NSCLC. Poor PS and serous effusion imply poor prognosis for NSCLC patients, most of which have adenocarcinomas and advanced stage.

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Acknowledgments

This study was partially supported by medical assistant Chao-Ping Chen of the cancer center.

Conflict of interest

There were no conflicts of interest.

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Authors and Affiliations

  1. Cancer Center, Guangdong Lung Cancer Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China

    Zhen Wang, Hong-Hong Yan, Jin-Ji Yang, Bin-Chao Wang, Hua-Jun Chen, Qing Zhou, Chong-Rui Xu, Ben-Yuan Jiang & Yi-Long Wu

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  1. Zhen Wang
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  2. Hong-Hong Yan
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  3. Jin-Ji Yang
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  4. Bin-Chao Wang
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  5. Hua-Jun Chen
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  6. Qing Zhou
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  7. Chong-Rui Xu
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  8. Ben-Yuan Jiang
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Correspondence to Yi-Long Wu.

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The English in this document has been checked by at least two professional editors, both native speakers of English. For a certificate, please see: http://www.textcheck.com/certificate/dyVTjV.

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Wang, Z., Yan, HH., Yang, JJ. et al. Venous thromboembolism risk factors in Chinese non-small cell lung cancer patients. Support Care Cancer 23, 635–641 (2015). https://doi.org/10.1007/s00520-014-2405-y

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  • DOI: https://doi.org/10.1007/s00520-014-2405-y

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