Supportive Care in Cancer

, Volume 21, Issue 5, pp 1359–1363

Antioxidant supplementation has a positive effect on oxidative stress and hematological toxicity during oncology treatment in cervical cancer patients


    • Servicio de OncologíaHospital General de México
    • Escuela Superior de MedicinaInstituto Politécnico Nacional
  • María Amanda Casillas Rivera
    • Universidad Iberoamericana
  • Karolina Alvarez Altamirano
    • Universidad Autónoma de Nuevo León
  • Juan Carlos Lopez-Alvarenga
    • Servicio de OncologíaHospital General de México
  • Guillermo Manuel Ceballos-Reyes
    • Escuela Superior de MedicinaInstituto Politécnico Nacional
Original Article

DOI: 10.1007/s00520-012-1674-6

Cite this article as:
Fuchs-Tarlovsky, V., Rivera, M.A.C., Altamirano, K.A. et al. Support Care Cancer (2013) 21: 1359. doi:10.1007/s00520-012-1674-6


Background and aim

Hematological toxicity and oxidative stress are common in cancer patients. Antioxidant supplementation has been shown to decrease oxidative stress, but there is still controversy on this topic. The aim of this study was to determine the effect of antioxidant supplementation on oxidative stress, hematological toxicity, and quality of life (QoL) in cervical cancer patients.


Randomized, single-blinded controlled trial in women with cervical cancer treated with radiotherapy and chemotherapy with cisplatin. Subjects were randomly assigned to receive antioxidant supplement or placebo supplement. Plasma concentrations of malondialdehyde, free carbonyls, and blood biometry were measured. EORTC quality of life questionnaire was applied before and after oncology treatment. Student’s t test for independent samples and X2 for categorical variables were performed.


One hundred three patients were randomly assigned to receive treatment with antioxidants 49 (48 %) or placebo 54 (52.40 %). At the end of the oncology treatment, hemoglobin levels were maintained, and global QoL was better only in the supplemented group (p < 0.025).


Antioxidant supplementation in patients treated with chemotherapy and radiotherapy apparently decreased oxidative stress, maintained hemoglobin levels, and improved QoL; however, more studies are needed to study the long-term effect of this intervention.


Cervical cancerOxidative stressAntioxidant therapyHematological toxicity and quality of life (QoL)

Copyright information

© Springer-Verlag Berlin Heidelberg 2012