Supportive Care in Cancer

, Volume 21, Issue 5, pp 1359–1363

Antioxidant supplementation has a positive effect on oxidative stress and hematological toxicity during oncology treatment in cervical cancer patients

  • Vanessa Fuchs-Tarlovsky
  • María Amanda Casillas Rivera
  • Karolina Alvarez Altamirano
  • Juan Carlos Lopez-Alvarenga
  • Guillermo Manuel Ceballos-Reyes
Original Article

DOI: 10.1007/s00520-012-1674-6

Cite this article as:
Fuchs-Tarlovsky, V., Rivera, M.A.C., Altamirano, K.A. et al. Support Care Cancer (2013) 21: 1359. doi:10.1007/s00520-012-1674-6

Abstract

Background and aim

Hematological toxicity and oxidative stress are common in cancer patients. Antioxidant supplementation has been shown to decrease oxidative stress, but there is still controversy on this topic. The aim of this study was to determine the effect of antioxidant supplementation on oxidative stress, hematological toxicity, and quality of life (QoL) in cervical cancer patients.

Methods

Randomized, single-blinded controlled trial in women with cervical cancer treated with radiotherapy and chemotherapy with cisplatin. Subjects were randomly assigned to receive antioxidant supplement or placebo supplement. Plasma concentrations of malondialdehyde, free carbonyls, and blood biometry were measured. EORTC quality of life questionnaire was applied before and after oncology treatment. Student’s t test for independent samples and X2 for categorical variables were performed.

Results

One hundred three patients were randomly assigned to receive treatment with antioxidants 49 (48 %) or placebo 54 (52.40 %). At the end of the oncology treatment, hemoglobin levels were maintained, and global QoL was better only in the supplemented group (p < 0.025).

Conclusions

Antioxidant supplementation in patients treated with chemotherapy and radiotherapy apparently decreased oxidative stress, maintained hemoglobin levels, and improved QoL; however, more studies are needed to study the long-term effect of this intervention.

Keywords

Cervical cancerOxidative stressAntioxidant therapyHematological toxicity and quality of life (QoL)

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Vanessa Fuchs-Tarlovsky
    • 1
    • 2
  • María Amanda Casillas Rivera
    • 3
  • Karolina Alvarez Altamirano
    • 4
  • Juan Carlos Lopez-Alvarenga
    • 1
  • Guillermo Manuel Ceballos-Reyes
    • 2
  1. 1.Servicio de OncologíaHospital General de MéxicoMexico D. F.Mexico
  2. 2.Escuela Superior de MedicinaInstituto Politécnico NacionalMexico CityMexico
  3. 3.Universidad IberoamericanaMéxico D. F.Mexico
  4. 4.Universidad Autónoma de Nuevo LeónMonterreyMexico