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Use of injectable spasticity management agents in a cancer center

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Abstract

Purpose

This study aims to analyze the utilization and effectiveness of injectable spasticity medications by the physiatry team at a referral-based tertiary cancer center.

Methods

A retrospective review and analysis of patient and injection characteristics were obtained from patients who had received onabotulinum toxin or phenol nerve block injections from December 1, 2007 through January 31, 2012. Out of 3,724 physiatry consultations during this period, 20 (less than 1 %) different cancer patients received a total of 54 total procedures.

Results

The majority of patients (17/20, 85 %) had a positive response to the injection. A positive response to the injection was defined by: (1) if the patient qualified to receive and was given another injection or (2) if there is a record of improvement if they did not receive another injection. A total of ten of 20 (50 %) patients received only one injection. Of these, seven of ten (70 %) reported a positive response to the injected agent. Those with only one injection tended to live farther away and die sooner. Four of 54 (7 %) injection procedures resulted in undesirable reported side effects (two for phenol, two for botulinum toxin). Nine of 54 (17 %) procedures occurred while the patients were on a chemotherapy protocol. All patients were injected at least 1 year out from initial diagnosis.

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Disclosures

Supported in part by the M.D. Anderson Cancer Center support grant R01CA016672. Eduardo Bruera is supported in part by National Institutes of Health grants RO1NR010162-01A1, RO1CA122292-01, and RO1CA124481-01. We certify that no party having a direct interest in the results of the research supporting this article has or will confer a benefit on us or on any organization with which we are associated and, if applicable, we certify that all financial and material supports for this research (e.g., NIH or NHS grants) and work are clearly identified.

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Authors and Affiliations

  1. Department of Palliative Care and Rehabilitation Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1414, TX 77030, Houston, USA

    Jack Fu, Carolina Gutiérrez, Eduardo Bruera, Ying Guo & Shana Palla

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  1. Jack Fu
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  2. Carolina Gutiérrez
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  3. Eduardo Bruera
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  4. Ying Guo
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  5. Shana Palla
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Correspondence to Jack Fu.

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Fu, J., Gutiérrez, C., Bruera, E. et al. Use of injectable spasticity management agents in a cancer center. Support Care Cancer 21, 1227–1232 (2013). https://doi.org/10.1007/s00520-012-1651-0

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  • DOI: https://doi.org/10.1007/s00520-012-1651-0

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