Prevalence and influence of malnutrition on quality of life and performance status in patients with locally advanced head and neck cancer before treatment
- Giorgio CapuanoAffiliated withClinical Nutrition Unit, Ospedale San Pietro—Fatebenefratelli Email author
- , Pier Carlo GentileAffiliated withOncology Department, Ospedale San Pietro—Fatebenefratelli
- , Federico BianciardiAffiliated withOncology Department, Ospedale San Pietro—Fatebenefratelli
- , Michela TostiAffiliated withOncology Department, Ospedale San Pietro—Fatebenefratelli
- , Anna PalladinoAffiliated withOncology Department, Ospedale San Pietro—Fatebenefratelli
- , Mario Di PalmaAffiliated withOncology Department, Ospedale San Pietro—Fatebenefratelli
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Goals of work
The aim of this study was to evaluate the prevalence and influence of malnutrition (unintentional weight loss ≥5% in the last 3 months) on quality of life (QoL) and performance status (PS) in head and neck cancer patients (HNC) before treatment.
Patients and methods
Sixty-one consecutive outpatients affected by locally advanced HNC (III–IVA stage) were enrolled. In all patients, nutritional intake (by diet history), nutritional status (Patient Generated Subjective Global Assessment), unintentional weight loss (UWL), serum prealbumin, hemoglobin level (Hb), C-reactive protein, QoL (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C-30 v. 3.0), and PS (Eastern Cooperative Oncology Group (ECOG) PS) were assessed before radio or concomitant chemoradiotherapy.
Thirty-six percent of HNC were malnourished before treatment. The median ECOG PS in malnourished patients was 1 (0–2), whereas in nonmalnourished was 0 (0–2; p = 0.018). Physical (p = 0.043), role (p = 0.047), and social functions (p = 0.024) scores were significantly worse in malnourished than in nonmalnourished HNC. Fatigue (p < 0.001), appetite loss (p < 0.001), and nausea and vomiting (p = 0.002) scores were worse in malnourished patients than in nonmalnourished. In the multivariate analysis, UWL and Hb level independently influenced physical (p = 0.002; p = 0.005), role (p = 0.004; p = 0.001), and social functions (p = 0.024; p = 0.009).
Our data suggest that an early and intensive nutritional support might reduce weight loss before, during, and after treatment completion, improving outcome, QoL, and PS.
KeywordsHead and neck cancer Weight loss Malnutrition Quality of life Performance status Nutritional support
- Prevalence and influence of malnutrition on quality of life and performance status in patients with locally advanced head and neck cancer before treatment
Supportive Care in Cancer
Volume 18, Issue 4 , pp 433-437
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Head and neck cancer
- Weight loss
- Quality of life
- Performance status
- Nutritional support
- Industry Sectors
- Author Affiliations
- 1. Clinical Nutrition Unit, Ospedale San Pietro—Fatebenefratelli, Via Cassia, 600-00189, Rome, Italy
- 2. Oncology Department, Ospedale San Pietro—Fatebenefratelli, Rome, Italy