Supportive Care in Cancer

, Volume 14, Issue 11, pp 1134–1140

A randomized controlled trial evaluating the efficacy and safety of vitamin E supplementation for protection against cisplatin-induced peripheral neuropathy: final results

  • Andreas A. Argyriou
  • Elisabeth Chroni
  • Angelos Koutras
  • Gregoris Iconomou
  • Spiridon Papapetropoulos
  • Panagiotis Polychronopoulos
  • Haralabos P. Kalofonos
Original Article

DOI: 10.1007/s00520-006-0072-3

Cite this article as:
Argyriou, A.A., Chroni, E., Koutras, A. et al. Support Care Cancer (2006) 14: 1134. doi:10.1007/s00520-006-0072-3

Abstract

Aim

A randomized, open label with blind assessment, controlled trial was performed to assess efficacy and adverse-event profile of vitamin E, given as supplementation for prophylaxis against cisplatin-induced peripheral neuropathy (CIPN).

Patients and methods

A total of 30 patients scheduled to receive six courses of cumulative cisplatin-based regimens were randomly allocated to treatment and control groups and were then studied by means of neurological examination and electrophysiological study. Patients assigned to group I (n=14) orally received vitamin E at a daily dose of 600 mg/day during chemotherapy and 3 months after its cessation were compared to patients of group II (n=16), who received no vitamin E supplementation and served as controls. The severity of neurotoxicity was summarized by means of a modified Peripheral Neuropathy (PNP) score.

Results

The incidence of neurotoxicity differed significantly between groups, occurring in 3/14 (21.4%) of patients assigned to the vitamin E supplementation group and in 11/16 (68.5%) of controls (p=0.026). The relative risk (RR) of developing neurotoxicity was significantly higher in case of controls, RR=2.51, 95% C.I.=1.16–5.47. Mean PNP scores were 4.99±1.33 for patients of group I and 10.47±10.62 for controls, (p=0.023). None of the adverse events or deaths occurred, were judged as likely to be related to the vitamin E supplementation.

Conclusion

Vitamin E effectively and safely protects patients with cancer from occurrence of cisplatin neurotoxicity.

Keywords

CisplatinPeripheral neuropathyVitamin ENeuroprotection

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Andreas A. Argyriou
    • 1
  • Elisabeth Chroni
    • 1
    • 3
  • Angelos Koutras
    • 2
  • Gregoris Iconomou
    • 2
  • Spiridon Papapetropoulos
    • 1
  • Panagiotis Polychronopoulos
    • 1
  • Haralabos P. Kalofonos
    • 2
  1. 1.EMG/ENG Laboratory, Department of NeurologyUniversity of Patras Medical SchoolRion-PatrasGreece
  2. 2.Division of Oncology, Department of MedicineUniversity of Patras Medical SchoolRion-PatrasGreece
  3. 3.Neurology DepartmentUniversity of Patras Medical SchoolRion-PatrasGreece