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Long-term predictors of anxiety and depression in adult patients with asthma

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Summary

Background

It is well established that anxiety and depression are associated with asthma, but there is limited evidence about the persistence of anxiety/depression in asthma. The aim of our study was to assess the long-term predictors of anxiety and depression in adult asthmatic patients.

Methods

A total of 90 adult asthma patients (63 women, age 18–50 years) with different levels of disease control (28 uncontrolled and 34 partially controlled) were assessed at baseline and at follow-up after 7 years for anxiety, depression and asthma control. The same work-up on both occasions included: demographics, living conditions, medical history (e.g. comorbidities, adherence and exacerbations), Hospital Anxiety and Depression Scale (HADS), Asthma Quality of Life Questionnaire (AQLQ), disease control and lung function. Persistence was defined as the HADS scores for anxiety and depression present at baseline and follow-up.

Results

The HADS results at follow-up visit showed 36 (40%) asthma patients with anxiety and 13 (14%) with depression, with the persistence of anxiety in 17 (19%) and of depression in 7 (8%) patients. Significant predictors of anxiety at follow-up were HADS and AQLQ results at baseline and several parameters of asthma control at follow-up (area under the curve AUC 0.917, 95% confidence interval CI 0.829–0.969, p < 0.001) and for depression AQLQ mood disorder domain, asthma control and lung function (AUC 0.947, 95% CI 0.870–0.986, p < 0.001).

Conclusion

Anxiety and depression persist over years in some patients with asthma. The association between mood disorders and asthma suggests potential mutual treatability.

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Authors and Affiliations

  1. Department of Pulmonology, University Hospital Center Osijek, Osijek, Croatia

    Marina Labor, Slavica Labor & Vladimir Fijačko

  2. Faculty of Medicine, J.J. Strossmayer University of Osijek, Osijek, Croatia

    Marina Labor, Slavica Labor, Vladimir Fijačko &  Davor Plavec MD PhD

  3. Department of Medicine, University Hospital Center Osijek, Osijek, Croatia

    Iva Jurić

  4. Department of Pulmonology, University Hospital Center Zagreb, Zagreb, Croatia

    Sanja Popović Grle

  5. Research Department, Children’s Hospital Srebrnjak, Srebrnjak 100, Zagreb, Croatia

    Davor Plavec MD PhD

Authors
  1. Marina Labor
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  2. Slavica Labor
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  4. Vladimir Fijačko
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  6. Davor Plavec MD PhD
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Corresponding author

Correspondence to Davor Plavec MD PhD.

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Conflict of interest

M. Labor, S. Labor, I. Jurić, V. Fijačko, S. Popović Grle, and D. Plavec declare that they have no competing interests.

Ethical standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.

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Labor, M., Labor, S., Jurić, I. et al. Long-term predictors of anxiety and depression in adult patients with asthma. Wien Klin Wochenschr 129, 665–673 (2017). https://doi.org/10.1007/s00508-017-1203-1

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  • DOI: https://doi.org/10.1007/s00508-017-1203-1

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