Abstract
Cases of adult renal cell carcinoma with rhabdoid features have been reported in the literature, usually in association with conventional clear cell and papillary tumors. Till date, only one report described chromophobe renal cell carcinoma with rhabdoid differentiation. We report a case of a 47-year-old male patient that underwent a routine medical check-up. Computer tomography scan revealed a large heterogeneous mass in the left kidney, multiple nodular changes in the lungs and multiple enlarged lymph nodes. On microscopic examination of the left nephrectomy specimen, 65 % of the kidney tumor was comprised of rhabdoid foci and the rest of the tumor showed eosinophilic areas consistent with chromophobe renal cell carcinoma. Final diagnosis was chromophobe renal cell carcinoma with rhabdoid differentiation. Behavior of these tumors in adults is more aggressive, demands more aggressive treatment and has poor prognosis. Therefore, rhabdoid differentiation should be recognized in this type of carcinoma and mentioned in the pathohistology report.
Zusammenfassung
In der Literatur wurde bisher über Fälle von Nierenkrebs mit rhabdoider Differenzierung normalerweise im Zusammenhang mit Klarzellkarzinomen und Pappilarkarzinomen berichtet. In der zugänglichen Literatur findet man nur einen Bericht von chromophobem Karzinom mit rhabdoider Differenzierung. Wir berichten über den Fall eines 47 Jahre alten männlichen Patienten, der einen routinemäßigen Check-up durchführte. Eine Computer-Tomographie ergab eine große heterogene Masse in der linken Niere, multiple noduläre Veränderungen in beiden Lungenflügeln und multiple vergrößerte Lymphknoten. Mikroskopische Untersuchungen der linken Niere zeigten, dass 65 % des Nierentumors aus rhabdoiden Bereichen bestanden und der Rest des Tumors eosinophile Bereiche aufwies, die mit einem chromophoben renalen Zellkarzinom konsistent waren. Die endgültige Diagnose ergab Chromophobes renales Zellkarzinom mit rhabdoider Differenzierung. Bei Erwachsenen zeigt diese Art von Tumoren eine erhöhte Aggressivität, erfordert aggressivere Behandlung und weist schlechte Erfolgsaussichten auf. Daher sollte rhabdoide Differenzierung im Zusammenhang mit dieser Art von Karzinomen erkannt und im pathohistologischen Bericht festgestellt werden.
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Brčić, I., Spajić, B. & Krušlin, B. Chromophobe renal cell carcinoma with rhabdoid differentiation in an adult. Wien Klin Wochenschr 124, 419–421 (2012). https://doi.org/10.1007/s00508-012-0189-y
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DOI: https://doi.org/10.1007/s00508-012-0189-y
Keywords
- Renal cell carcinoma
- Rhabdoid differentiation
- Chromophobe renal cell carcinoma
- Nephrectomy
- Neoplasm metastasis
- Morphology