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Reversible diabetes mellitus during growth hormone therapy in chronic renal failure

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Abstract.

A 12-year-old girl with short stature due to idiopathic Fanconi syndrome and chronic renal failure was treated with recombinant human growth hormone (rhGH). There was no family history of diabetes mellitus and the glucose tolerance before treatment was normal. Intravenous glucose tolerance tests were performed before, during and after treatment. Two months after starting rhGH the early phase of insulin secretion (1-+3-min values) was diminished, and the patient developed manifest diabetes mellitus with hyperglycemia and an elevated hemoglobin A1c. Following discontinuation of rhGH, glucose tolerance slowly returned to normal.

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Authors and Affiliations

  1. Department of Pediatric Nephrology, Charité Children’s Hospital, Humboldt University, Berlin, Germany, , , , , , DE

    Guido Filler, Doris Franke & Jochen H. H. Ehrich

  2. Division of Pediatric Endocrinology, Charité Children’s Hospital, Humboldt University, Berlin, Germany, , , , , , DE

    Peter Amendt

Authors
  1. Guido Filler
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  2. Doris Franke
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  3. Peter Amendt
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  4. Jochen H. H. Ehrich
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Additional information

Received May 29, 1997; received in revised form November 5, 1997; accepted November 12, 1997

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Filler, G., Franke, D., Amendt, P. et al. Reversible diabetes mellitus during growth hormone therapy in chronic renal failure. Pediatr Nephrol 12, 405–407 (1998). https://doi.org/10.1007/s004670050475

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  • DOI: https://doi.org/10.1007/s004670050475

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