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Left ventricular mass and diastolic function in obese children and adolescents

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Abstract

Background

Our aims were to assess left ventricular structure and diastolic function in obese subjects stratified according to ambulatory blood pressure status, and to investigate independent predictors of the left ventricular mass (LVM) index.

Methods

Obese subjects aged 9–19 years referred for ambulatory blood pressure monitoring (ABPM) were evaluated in the cross-sectional study. In addition to biochemical and anthropometric measurements, subjects underwent ABPM, Doppler echocardiography, and treadmill exercise test.

Results

According to ABPM results, 103 subjects with obesity (mean age 14.1 ± 2 years) were split in two groups: 49 hypertensive, and 54 without hypertension. Left ventricular hypertrophy was found in 16.3 % of hypertensive, and 5.6 % of normotensive. Variables included in stepwise regression analysis as potential determinants of LVM index were age, body mass index z score, waist circumference, peak systolic blood pressure on exercise test, 24-h heart rate, and night heart rate. Peak systolic blood pressure (adjusted R2 = 0.051, β = 0.245, p = 0.013) remained as the independent predictor of LVM index. Diastolic function evaluated by mitral E/A ratio was decreased in both obese groups.

Conclusions

Early markers of cardiac disease including hypertrophy and diastolic dysfunction of the left ventricle are present in youths with obesity prior to the development of sustained hypertension.

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Acknowledgments

The study was supported by the Ministry of Science and Environmental Protection, Government of Serbia, Grants no. 175079

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Authors and Affiliations

  1. Nephrology Department, University Children’s Hospital, Tiršova 10, 11 000, Belgrade, Serbia

    Paripović Dušan, Miloševski-Lomić Gordana & Peco-Antić Amira

  2. Cardiology Department, University Children’s Hospital, Belgrade, Serbia

    Ilisić Tamara & Vukomanović Goran

  3. School of Medicine, University of Belgrade, Belgrade, Serbia

    Peco-Antić Amira

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  1. Paripović Dušan
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  2. Ilisić Tamara
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  3. Vukomanović Goran
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Correspondence to Paripović Dušan.

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Dušan, P., Tamara, I., Goran, V. et al. Left ventricular mass and diastolic function in obese children and adolescents. Pediatr Nephrol 30, 645–652 (2015). https://doi.org/10.1007/s00467-014-2992-3

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  • DOI: https://doi.org/10.1007/s00467-014-2992-3

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