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Increased incidence of adenoidectomy and tonsillectomy in children with renal transplantation

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Abstract

Background

Previous studies have found that pediatric solid organ transplant recipients suffer from adenotonsillar hyperplasia. However, as this condition is also common in normal children, it remains unclear whether the incidence is truly increased. The aim of this study was to compare the incidences of surgery on the adenoids and tonsils of normal children with those receiving renal transplants and to define risk factors in the transplant population.

Methods

Data on 49 consecutive children from a single renal transplant unit were compared to data from a large governmental survey of healthy German children (KiGGS). For analysis of ‘survival without operation’, controls were matched for gender, region and immigration status (n = 8,650), as well as for age to compare incidence rates (n = 637).

Results

The age-matched solid organ transplant recipients had a higher incidence of adenoidectomies [2.3-fold, [95 % confidence interval (CI) for relative risk 1.6–3.3) and a higher incidence of tonsillectomies/tonsillotomies (3.5-fold, 95 % CI 2.1–5.7). The normal peak of adenoidectomies was delayed by 2 years in the pre-school group, and transplanted teenagers showed an extra peak for both operations. Boys and those transplanted at a younger age were significantly more likely to need adenoidectomies. Ciclosporin levels, Epstein–Barr virus and cytomegalovirus infections did not influence the incidence of operations.

Conclusion

Children receiving renal transplants are at markedly increased risk of adenotonsillar hyperplasia requiring surgery, especially males and young recipients.

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Notes

  1. 5 EBV positive children had already undergone complete removal of their tonsils before transplantation and are therefore not included in the calculation of risk for tonsillectomy after transplantation.

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Acknowledgments

The authors thank the Robert Koch Institute for the provision of data on healthy children from the KiGGS Study [1].

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Correspondence to Charlotte Gimpel.

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Gimpel, C., Heinrich, A., Fehrenbach, H. et al. Increased incidence of adenoidectomy and tonsillectomy in children with renal transplantation. Pediatr Nephrol 29, 1441–1450 (2014). https://doi.org/10.1007/s00467-014-2775-x

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  • DOI: https://doi.org/10.1007/s00467-014-2775-x

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