Pediatric Nephrology

, Volume 28, Issue 3, pp 409–414

Treatment of steroid-resistant nephrotic syndrome in children: new guidelines from KDIGO

Authors

    • Division of Nephrology, Department of Pediatrics and Communicable DiseasesUniversity of Michigan
    • Pediatric NephrologyC.S. Mott Children’s Hospital
  • Elisabeth M. Hodson
    • Centre for Kidney ResearchThe Children’s Hospital at Westmead
    • Sydney School of Public HealthUniversity of Sydney
  • Debbie S. Gipson
    • Division of Nephrology, Department of Pediatrics and Communicable DiseasesUniversity of Michigan
    • Michigan Institute for Clinical and Health ResearchUniversity of Michigan
Educational Review

DOI: 10.1007/s00467-012-2304-8

Cite this article as:
Lombel, R.M., Hodson, E.M. & Gipson, D.S. Pediatr Nephrol (2013) 28: 409. doi:10.1007/s00467-012-2304-8

Abstract

Kidney Disease: Improving Global Outcomes (KDIGO) recently published the clinical practice guideline on glomerulonephritis (GN) to assist the practitioner caring for patients with GN. Chapter 4 of the guideline focuses on managing children aged 1–18 years with steroid-resistant nephrotic syndrome (SRNS), defined by an inability to achieve complete remission with corticosteroid therapy. Guideline development followed a thorough evidence review, and management recommendations and suggestions were based on the best available evidence. Limitations of the evidence, including the paucity of large-scale randomized controlled trials, are discussed. This article provides both the guideline recommendations and a brief review of relevant treatment trials related to each recommendation. This précis serves as a summary of the complete guidelines recently published.

Keywords

Clinical practice guidelinesSteroid-resistant nephrotic syndromeChildrenManagement

Copyright information

© IPNA 2012