Educational Review

Pediatric Nephrology

, Volume 28, Issue 3, pp 409-414

Treatment of steroid-resistant nephrotic syndrome in children: new guidelines from KDIGO

  • Rebecca M. LombelAffiliated withDivision of Nephrology, Department of Pediatrics and Communicable Diseases, University of MichiganPediatric Nephrology, C.S. Mott Children’s Hospital Email author 
  • , Elisabeth M. HodsonAffiliated withCentre for Kidney Research, The Children’s Hospital at WestmeadSydney School of Public Health, University of Sydney
  • , Debbie S. GipsonAffiliated withDivision of Nephrology, Department of Pediatrics and Communicable Diseases, University of MichiganMichigan Institute for Clinical and Health Research, University of Michigan

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Kidney Disease: Improving Global Outcomes (KDIGO) recently published the clinical practice guideline on glomerulonephritis (GN) to assist the practitioner caring for patients with GN. Chapter 4 of the guideline focuses on managing children aged 1–18 years with steroid-resistant nephrotic syndrome (SRNS), defined by an inability to achieve complete remission with corticosteroid therapy. Guideline development followed a thorough evidence review, and management recommendations and suggestions were based on the best available evidence. Limitations of the evidence, including the paucity of large-scale randomized controlled trials, are discussed. This article provides both the guideline recommendations and a brief review of relevant treatment trials related to each recommendation. This précis serves as a summary of the complete guidelines recently published.

Keywords

Clinical practice guidelines Steroid-resistant nephrotic syndrome Children Management