Review

Pediatric Nephrology

, Volume 22, Issue 11, pp 1825-1838

Open Access This content is freely available online to anyone, anywhere at any time.

Molecular regulation of kidney development: is the answer blowing in the Wnt?

  • Calli E. MerkelAffiliated withDepartments of Internal Medicine (Nephrology) and Molecular Biology, University of Texas Southwestern Medical Center
  • , Courtney M. KarnerAffiliated withDepartments of Internal Medicine (Nephrology) and Molecular Biology, University of Texas Southwestern Medical Center
  • , Thomas J. CarrollAffiliated withDepartments of Internal Medicine (Nephrology) and Molecular Biology, University of Texas Southwestern Medical Center Email author 

Abstract

Development of the metanephric kidney is a complicated process regulated by reciprocal signals from the ureteric bud and the metanephric mesenchyme that regulate tubule formation and epithelial branching morphogenesis. Over the past several years, several studies have suggested that Wnt signaling is involved in multiple aspects of normal kidney development as well as injury response and cancer progression. We will review these data here.

Keywords

Renal vesicle Ureteric bud β-Catenin Metanephros