Abstract
Glomerular disease constitutes an important part of renal disease. The purpose of this study was to describe and correlate the types of glomerular diseases reported in native kidney biopsy specimens and their clinical presentations in Iranian children. The medical records and pathological diagnoses of patients with glomerular disease whose native kidney biopsy specimens were received by our hospital during a 10-year period were reviewed. In each patient, pathological diagnosis, clinical presentation, age at onset of disease, gender, and presence of nephrotic proteinuria, hematuria, and hypertension, were determined. Minimal-change disease was the most frequent glomerular disease and nephrotic syndrome was the most frequent clinical presentation encountered. For each disease, correlations between the clinical presentation and pathological diagnosis were made. This study describes various glomerular diseases encountered in Iranian children, with their respective clinical presentations.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bernstein J, Edelmann CM (1992) Glomerular diseases: Introduction and classification. In: Edelmann CM (ed) Pediatric kidney disease, 2nd edn, Little Brown, Boston, pp 1181–1188
Churg J, Sobin LH (1982) Renal disease: classification and atlas of glomerular diseases. Igaku- Shoin, Tokio, pp3–19
Al-Rasheed SA, Al-Mugeiren MM, Al-Salloum AA, Al-Sohaibani MO (1996) Childhood renal disease in Saudi-Arabia. A clinico-pathological study of 167 cases. Int Urol Nephrol 28(5):607–613
Gianoglio B(1998) From the Italian registry of pediatric renal biopsies: 1992–1994. Pediatr Nephrol 12:C225
Mattoo TK (1994) Pediatric Nephrology in the Arabian Peninsula. In: Holliday MA, Barratt TM, Avner ED (eds) Pediatric nephrology, 3rd edn, Williams & Wilkins, Baltimore, pp:1436–1437
Thirakhupt P (1994) Pediatric nephrology around the world:Thailand. In: Holliday MA, Barratt TM & Avner ED (eds) Pediatric Nephrology, 3rd edn, Williams & Wilkins, Baltimore, pp 1444
Alfiler CA, Srivastava RN, Chiu CM (1999) Pediatric nephrology around the world: Asia. In: Barratt TM, Avner ED, Harmon WE (eds) Pediatric Nephrology, 4thedn, Lippincott, Baltimore, pp 1357–1362
ISKDC (1981) The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone. J Pediatr 98:561–564
Habib R, Kleinknecht C (1971) The primary nephrotic syndrome of childhood: classification and clinicopathologic study of 406 cases. In: Sommers, SC ed, Pathology annual, Appleton, New York, p 417
Cameron Js (1968) Histology, protein clearances and response to treatment in the nephrotic syndrome. Br. Med J 4:352
White RHR, Glasgow EP, Mills RJ (1970) Clinico-pathological study of nephrotic syndrome in children. Lancet 1:1353–1359
Churg J, White RHR, Habib R (1970) Pathology of the nephrotic syndrome in children. Lancet 1:1299–1302
Srivastava T, Simon SD, Alon US (1999) High incidence of FSGS in nephrotic syndrome of childhood. Pediatr Nephrol 13:13–18
D'Agati V (1994) The many masks of focal segmental glomerulosclerosis. Kidney Int 46:1223–1241
Chen WP, lin CY,Hso Hc, Chiang H (1988) Childhood nephrotic syndrome and heavy proteinuria in Taiwan: a retrospective clinicopathologic study. Child Nephrol Urol 9:57
Coovadia HM, Eke F, Luta M (1999) Pediatric nephrology around the world: Africa. In: Barratt TM, Avner ED, Harmon WE (eds) Pediatric Nephrology 4th edn, Lippincott, Baltimore, p 1364
Bhimma R, Coovadia HM, Adhikari M (1997) Nephrotic syndrome in South African children: changing perspectives over 20 years. Pediatr Nephrol 11:429–434
Jennette JC (1998) Prologue to Section II. In: Jennette JC, Olson JL, Schwartz MM, Silva FG (eds), Heptinstall's pathology of the kidney, 5th edn, Little Brown, Boston, p 182
Piqueras AI, White RHR, Raafat F, Moghal N, Milford DV (1998) Renal biopsy diagnosis in children presenting with hematuria. Pediatr Nephrol 12:386–391
Acknowledgement
The authors wish to thank A. Mahyar, MD for his assistance in preparing the manuscript.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Madani, A., Fahimi, D., Esfehani, S.T. et al. Glomerular diseases in Iranian children: clinico-pathological correlations. Pediatr Nephrol 18, 925–928 (2003). https://doi.org/10.1007/s00467-003-1166-5
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00467-003-1166-5