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The effect of rs9939609 FTO gene polymorphism on weight loss after laparoscopic sleeve gastrectomy

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Abstract

Purpose

Remarkable differences in weight loss have been observed in obese patients undergoing laparoscopic sleeve gastrectomy (LSG). These high variations might be partly explained by genetic factors. The rs9939609 fat mass and obesity-associated gene (FTO) polymorphism has been implicated in the susceptibility of obesity. We aimed to explore the effects of the rs9939609 FTO gene polymorphism on weight loss among severely obese patients applying for LSG.

Materials and methods

All individuals were analyzed for the FTO rs9939609 gene polymorphism. A total of 74 morbid obese patients (20 male, 54 female) were operated. Body weight and body mass index (BMI) were measured at before LSG and after surgery at the sixth month.

Results

Twenty-eight patients (37.8 %) had genotype TT (wild-type allel), 36 patients (48.6 %) had genotype TA, and 10 patients (13.5 %) had genotype AA. In both wild-type group and mutant group, BMI and weight levels decreased at the sixth month after surgery. Percent of excess weight loss (EWL) at 6 months of follow-up was similar in both groups. There were no differences between the mutant and wild-type groups percent of EWL at the sixth month after applying LSG.

Conclusion

Our data showed that the rs9939609 FTO gene polymorphism is not a useful genetic test prior to LSG to help clinicians predicting the weight loss for severely obese patients in short-term follow-up.

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Acknowledgments

This work was supported by Antalya Education and Research Hospital (Grant Number: 81266704).

Disclosures

Özgür Balasar, Tuğrul Çakır, Özgür Erkal, Arif Aslaner, Bülent Çekiç, Mehmet Uyar, Nurullah Bülbüller and Mehmet Tahir Oruç declare that they have no conflict of interest in relation to this work.

Author information

Authors and Affiliations

  1. Department of Medical Genetics, Dr. Faruk Sükan Maternity and Pediatric Hospital, Konya, Turkey

    Özgür Balasar

  2. General Surgery Department, Antalya Training and Research Hospital, Muratpaşa, Antalya, 07000, Turkey

    Tuğrul Çakır, Arif Aslaner, Nurullah Bülbüller & Mehmet Tahir Oruç

  3. Department of Medical Genetics, Antalya Training and Research Hospital, Muratpaşa, Antalya, Turkey

    Özgür Erkal

  4. Radiology Department, Antalya Training and Research Hospital, Muratpaşa, Antalya, Turkey

    Bülent Çekiç

  5. Department of Public Health, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey

    Mehmet Uyar

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  1. Özgür Balasar
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Correspondence to Tuğrul Çakır.

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Balasar, Ö., Çakır, T., Erkal, Ö. et al. The effect of rs9939609 FTO gene polymorphism on weight loss after laparoscopic sleeve gastrectomy. Surg Endosc 30, 121–125 (2016). https://doi.org/10.1007/s00464-015-4169-y

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  • DOI: https://doi.org/10.1007/s00464-015-4169-y

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