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The laparoscopic nissen-hill hybrid: pilot study of a combined antireflux procedure

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Abstract

Background

Laparoscopic antireflux surgery is highly effective in patients with uncomplicated gastroesophageal reflux disease (GERD). However, long-term failure rates in paraesophageal hernia (PEH) and Barrett’s metaplasia (BE) are higher and warrant a more durable repair. Outcomes for the laparoscopic Nissen fundoplication (LNF) and Hill repair (LHR) are equivalent, but their anatomic components are different and may complement each other (Aye R Ann Thorac Surg, 2012). We designed and tested the feasibility and safety of an operation that combines the essential components of each repair.

Methods

A prospective, phase II pilot study was performed on patients with symptomatic giant PEH hernias and/or GERD with nondysplastic Barrett’s metaplasia. Pre- and postoperative esophagogastroduodenoscopy (EGD), upper gastrointestinal study (UGI), 48-hour pH testing, manometry, and three quality-of-life metrics were obtained.

Results

Twenty-four patients were enrolled in the study. Three patients did not complete the planned procedure, leaving 21 patients, including 12 with PEH, 7 with BE, and 2 with both. There were no 30-day or in-hospital mortalities. At a median follow-up of 13 (range 6.4–30.2) months, there were no reoperations or clinical recurrences. Two patients required postoperative dilation for dysphagia, with complete resolution. Mean DeMeester scores improved from 54.3 to 7.5 (p < 0.0036). Mean lower esophageal sphincter pressures (LESP) increased from 8.9 to 21.3 mmHg (p < 0.013). Mean short-term and long-term QOLRAD scores improved from 4.09 at baseline to 6.04 and 6.48 (p < 0.0001). Mean short-term and long-term GERD-HQRL scores improved from 22.9 to 7.5 and 6.9 (p < 0.03). Mean long-term Dysphagia Severity Score Index improved from 33.3 to 40.6 (p < 0.064).

Conclusions

The combination of a Nissen plus Hill hybrid reconstruction of the gastroesophageal junction (GEJ) is technically feasible, safe, and not associated with increased side effects. Short-term clinical results in PEH and BE suggest that this may be an effective repair, supporting the value of further study.

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Acknowledgments

The authors acknowledge the contributions of Justine Rees, The Ryan Hill Foundation, and the Swedish Foundation.

Disclosures

Drs. Qureshi, Aye, Buduhan, Orlina, Farivar, Wagner, Louie, Ms. Ariel Knight, and Mr. Sean McHugh have no conflicts of interest or financial ties to disclose.

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Authors and Affiliations

  1. University of Toronto, Toronto, ON, Canada

    Alia P. Qureshi

  2. Thoracic and Esophageal Surgery, Swedish Cancer Institute, 1101 Madison Avenue, Suite 850, Seattle, WA, 98103, USA

    Ralph W. Aye, Alexander S. Farivar, Oliver J. Wagner, Sean McHugh & Brian E. Louie

  3. Dalhousie University, Thoracic Surgery, Halifax, NS, Canada

    Gordon Buduhan

  4. University of Washington, Medical School, Seattle, WA, USA

    Ariel Knight

  5. Western Connecticut Medical Group Surgery, Danbury, CT, USA

    Jeraldine Orlina

Authors
  1. Alia P. Qureshi
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  2. Ralph W. Aye
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  3. Gordon Buduhan
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  4. Ariel Knight
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  6. Alexander S. Farivar
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  7. Oliver J. Wagner
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  8. Sean McHugh
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  9. Brian E. Louie
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Corresponding author

Correspondence to Ralph W. Aye.

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Qureshi, A.P., Aye, R.W., Buduhan, G. et al. The laparoscopic nissen-hill hybrid: pilot study of a combined antireflux procedure. Surg Endosc 27, 1945–1952 (2013). https://doi.org/10.1007/s00464-012-2692-7

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  • DOI: https://doi.org/10.1007/s00464-012-2692-7

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