, Volume 26, Issue 6, pp 385-391

Performance prediction of industrial centrifuges using scale-down models

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Abstract

Computational fluid dynamics was used to model the high flow forces found in the feed zone of a multichamber-bowl centrifuge and reproduce these in a small, high-speed rotating disc device. Linking the device to scale-down centrifugation, permitted good estimation of the performance of various continuous-flow centrifuges (disc stack, multichamber bowl, CARR Powerfuge TM) for shear-sensitive protein precipitates. Critically, the ultra scale-down centrifugation process proved to be a much more accurate predictor of production multichamber-bowl performance than was the pilot centrifuge.

Paper presented in part at the International Conference on Trends in Monitoring and Control of Life Science Applications, 7–8 October 2002, Lyngby, Denmark