Original Paper

Bioprocess and Biosystems Engineering

, Volume 26, Issue 6, pp 385-391

Performance prediction of industrial centrifuges using scale-down models

  • M. BoychynAffiliated withThe Advanced Centre for Biochemical Engineering, University College LondonEli Lilly and Co.
  • , S. S. S. YimAffiliated withThe Advanced Centre for Biochemical Engineering, University College London
  • , M. BulmerAffiliated withBio Products Laboratory
  • , J. MoreAffiliated withBio Products Laboratory
  • , D. G. BracewellAffiliated withThe Advanced Centre for Biochemical Engineering, University College LondonThe EPSRC IMRC for Bioprocessing, University College London
  • , M. HoareAffiliated withThe Advanced Centre for Biochemical Engineering, University College LondonThe EPSRC IMRC for Bioprocessing, University College London Email author 

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Abstract

Computational fluid dynamics was used to model the high flow forces found in the feed zone of a multichamber-bowl centrifuge and reproduce these in a small, high-speed rotating disc device. Linking the device to scale-down centrifugation, permitted good estimation of the performance of various continuous-flow centrifuges (disc stack, multichamber bowl, CARR Powerfuge TM) for shear-sensitive protein precipitates. Critically, the ultra scale-down centrifugation process proved to be a much more accurate predictor of production multichamber-bowl performance than was the pilot centrifuge.

Keywords

Centrifugation Scale-down Shear Clarification