Cell and Tissue Research

, Volume 298, Issue 2, pp 371–375

Potentiation of myoblast transplantation by host muscle irradiation is dependent on the rate of radiation delivery

Authors

  • Jacqueline G. Gross
    • Muscle Cell Biology, Medical Research Council Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
  • George Bou-Gharios
    • Muscle Cell Biology, Medical Research Council Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
  • Jennifer E. Morgan
    • Muscle Cell Biology, Medical Research Council Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
Short Communication

DOI: 10.1007/s004419900062

Cite this article as:
Gross, J., Bou-Gharios, G. & Morgan, J. Cell Tissue Res (1999) 298: 371. doi:10.1007/s004419900062

Abstract.

Transplantation of muscle precursor cells (mpc) has been suggested as a treatment for myopathies, such as Duchenne muscular dystrophy. Irradiation of skeletal muscle with 16–20 Gy prevents muscle regeneration and also augments muscle formation from implanted muscle precursor cells (mpc). However, when mdx nu/nu mouse muscles are preirradiated at 0.73 Gy/min rather than at 1.29 Gy/min prior to their injection with normal mpc, significantly more muscle fibres of donor origin are formed. This suggests that the rate at which irradiation is delivered has a physiological effect on the muscle. Although it would not be feasible to irradiate a patient's muscles prior to mpc implantation, once the factor(s) which are altered in irradiated muscle have been identified, it might be possible to use these to increase the success of myoblast transplantation.

Radiation Myoblast transplantation therapy Muscle regeneration Mouse (mdx nu/nu)

Copyright information

© Springer-Verlag 1999