Regular Article

Cell and Tissue Research

, Volume 297, Issue 1, pp 103-110

Expression of a novel member of the TGF-β superfamily, growth/differentiation factor-15/macrophage-inhibiting cytokine-1 (GDF-15/MIC-1) in adult rat tissues

  • Martina BöttnerAffiliated withDepartment of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, D-69120 Heidelberg, Germany e-mail: klaus.unsicker@urz.uni-heidelberg.de; Tel.: +49 6221 54 82 27; Fax: +49 6221 54 56 04
  • , Clemens Suter-CrazzolaraAffiliated withDepartment of Neuroanatomy, Medical School, Carl Neuberg Str. 1, D-30625 Hannover, Germany
  • , Andreas SchoberAffiliated withDepartment of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, D-69120 Heidelberg, Germany e-mail: klaus.unsicker@urz.uni-heidelberg.de; Tel.: +49 6221 54 82 27; Fax: +49 6221 54 56 04
  • , K. UnsickerAffiliated withDepartment of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, D-69120 Heidelberg, Germany e-mail: klaus.unsicker@urz.uni-heidelberg.de; Tel.: +49 6221 54 82 27; Fax: +49 6221 54 56 04

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Abstract 

We have cloned a novel member of the transforming growth factor-β (TGF-β) superfamily from a human placental cDNA library. The sequence is identical to five very recently published sequences, of which only one (macrophage inhibitory cytokine-1, MIC-1) has been characterized in terms of function. In light of the present data demonstrating the wide distribution of the mRNA and putative multifunctionality, we propose to name this molecule growth/differentiation factor-15/MIC-1 (GDF-15/MIC-1). The deduced amino acid sequence reveals typical features of a secreted molecule. The epithelium of the choroid plexus is the only site in the adult brain expressing detectable levels of GDF-15/MIC-1 mRNA. Many epithelia of non-neural tissues including those of the prostate and intestinal mucosa, bronchi and bronchioli, secretory tubuli of the submandibular gland, and lactating mammary gland are prominent sites of GDF-15/MIC-1 synthesis. GDF-15/MIC-1 is also strongly expressed by macrophages in the adrenal gland. Thus, GDF-15/MIC-1, like many other members of the TGF-β superfamily, is widely distributed in adult tissues, being most strongly expressed in epithelial cells and macrophages.

Key words TGF-β CNS Epithelial tissues Macrophages Rat (Wistar)