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The vertebrate homologue of sulfide-quinone reductase in mammalian mitochondria

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Abstract

Hydrogen sulfide (H2S) is the first inorganic compound identified as both a substrate for mitochondrial oxidative phosphorylation and a transmitter in mammalian cells. H2S seems to mediate effects that are correlated with those of nitric oxide (NO) by a reciprocal regulation. Moreover, H2S is consumed by mitochondrial oxidation mediated by sulfide-quinone reductase-like protein (SQRDL)—the vertebrate homolog of sulfide-quinone oxidoreductase (SQR). There is evidence that SQR plays an essential role in regulating H2S levels in fission yeast. To start understanding the role of SQRDL in the mammalian metabolism of H2S, we examine rat tissues. Our results show that SQRDL protein is present in all tissues tested, albeit restricted to specific mitochondrial populations at the cellular level. We demonstrate a developmental regulation of Sqrdl transcription in the kidney, where SQRDL protein is detectable in glomerular podocytes and in tubular cells of the renal medulla. We also show that Sqrdl transcription in T cells is responsive to external H2S. Taken together, our results suggest that Sqrdl transcription is adaptively regulated, probably to meet the need of H2S oxidation. Thus far, SQRDL has only been studied in a limited set of tissues. The present report demonstrates the presence and specific localization of SQRDL in various mammalian tissues.

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Acknowledgments

We thank Prof. Dr. Alexander Brawanski for his support during the development of this work. We also thank Prof. Dr. Ralph Witzgall, for helpful comments and experimental support. Further thanks go to B. Banas, M. Rehli and K. Renner for providing material and expertise and to C.-L. Schengrund for reviewing this manuscript.

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Authors and Affiliations

  1. Department of Neurosurgery, University Clinic of Regensburg, Regensburg, Germany

    M. Ackermann, M. Kubitza & A. L. Piña

  2. Institute for Botany, University of Regensburg, Regensburg, Germany

    G. Hauska

  3. Max-Planck-Institut für Biochemie, Am Klopferspitz 18, 82152, Martinsried, Germany

    M. Ackermann

  4. Institute for Molecular and Cellular Anatomy, University of Regensburg, Regensburg, Germany

    M. Kubitza

  5. Department of Neurosurgery and Berlin-Brandenburg Center for Regenerative Therapies, Charité Berlin Medical University, Campus Mitte, Chariteplatz 1/Virchowweg 21, Ashheim-Zondek-Haus 03-003, 10117, Berlin, Germany

    A. L. Piña

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  1. M. Ackermann
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Ackermann, M., Kubitza, M., Hauska, G. et al. The vertebrate homologue of sulfide-quinone reductase in mammalian mitochondria. Cell Tissue Res 358, 779–792 (2014). https://doi.org/10.1007/s00441-014-1983-9

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