At-a-Glance Article

Cell and Tissue Research

, Volume 344, Issue 2, pp 189-205

Protein tyrosine phosphatase interacting protein 51—a jack-of-all-trades protein

  • Alexander BrobeilAffiliated withInstitute of Anatomy and Cell Biology, Justus-Liebig-University
  • , Manuel BobrichAffiliated withInstitute of Anatomy and Cell Biology, Justus-Liebig-University
  • , Monika WimmerAffiliated withInstitute of Anatomy and Cell Biology, Justus-Liebig-University Email author 

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Abstract

Protein tyrosine phosphatase interacting protein 51 (PTPIP51) interacts both in vitro and in vivo with PTP1B, a protein tyrosine phosphatase involved in cellular regulation. PTPIP51 is known to be expressed in many different types of tissues. It is involved in cellular processes such as proliferation, differentiation and apoptosis. Nevertheless, the exact cellular function of PTPIP51 is still unknown. The present review summarizes our current knowledge of the PTPIP51 gene and its mRNA and protein structure.

Keywords

PTPIP51 Gene regulation mRNA structure Protein domains Isoforms