Human Genetics

, Volume 103, Issue 1, pp 48–50

Elite endurance athletes and the ACE I allele – the role of genes in athletic performance

Authors

  • George Gayagay
    • Department of Molecular & Clinical Genetics, Royal Prince Alfred Hospital, Camperdown NSW 2050, Australia e-mail: rtrent@med.usyd.edu.au, Fax: +61-2-95157595
  • Bing Yu
    • Department of Molecular & Clinical Genetics, Royal Prince Alfred Hospital, Camperdown NSW 2050, Australia e-mail: rtrent@med.usyd.edu.au, Fax: +61-2-95157595
  • Brett Hambly
    • Department of Pathology, University of Sydney NSW 2006, Australia
  • Tanya Boston
    • Australian Institute of Sport, Canberra ACT 2617, Australia
  • Alan Hahn
    • Australian Institute of Sport, Canberra ACT 2617, Australia
  • David S. Celermajer
    • Department of Cardiology, Royal Prince Alfred Hospital, Camperdown NSW 2050, Australia
  • R. J. Trent
    • Department of Molecular & Clinical Genetics, Royal Prince Alfred Hospital, Camperdown NSW 2050, Australia e-mail: rtrent@med.usyd.edu.au, Fax: +61-2-95157595
Original investigation

DOI: 10.1007/s004390050781

Cite this article as:
Gayagay, G., Yu, B., Hambly, B. et al. Hum Genet (1998) 103: 48. doi:10.1007/s004390050781

Abstract

Genetic markers that might contribute to the making of an elite athlete have not been identified. Potential candidate genes might be found in the renin-angiotensin pathway, which plays a key role in the regulation of both cardiac and vascular physiology. In this study, DNA polymorphisms derived from the angiotensin converting enzyme (ACE), the angiotensin type 1 receptor (AT1) and the angiotensin type 2 receptor (AT2) were studied in 64 Australian national rowers. Compared with a normal population, the rowers had an excess of the ACE I allele (P<0.02) and the ACE II genotype (P=0.03). The ACE I allele is a genetic marker that might be associated with athletic excellence. It is proposed that the underlying mechanism relates to a healthier cardiovascular system.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998