Human Genetics

, Volume 107, Issue 6, pp 582–590

Y chromosome haplotypes reveal prehistorical migrations to the Himalayas

Authors

  • Bing Su
    • Human Genetics CenterUniversity of Texas-Houston
    • Institute of Genetics, School of Life SciencesFudan University and Morgan-Tan International Center for Life Sciences
    • Kunming Institute of ZoologyChinese Academy of Sciences
  • Chunjie Xiao
    • Human Genetics CenterUniversity of Texas-Houston
    • Department of BiologyYunnan University
  • Ranjan Deka
    • Department of Environmental HealthUniversity of Cincinnati
  • Mark T. Seielstad
    • Program for Population GeneticsHarvard School of Public Health
  • Daoroong Kangwanpong
    • Department of BiologyChiang Mai University
  • Junhua Xiao
    • Institute of Genetics, School of Life SciencesFudan University and Morgan-Tan International Center for Life Sciences
  • Daru Lu
    • Institute of Genetics, School of Life SciencesFudan University and Morgan-Tan International Center for Life Sciences
  • Peter Underhill
    • Department of GeneticsStanford University
  • Luca Cavalli-Sforza
    • Department of GeneticsStanford University
  • Ranajit Chakraborty
    • Human Genetics CenterUniversity of Texas-Houston
    • Human Genetics CenterUniversity of Texas-Houston
    • Institute of Genetics, School of Life SciencesFudan University and Morgan-Tan International Center for Life Sciences
Original Investigations

DOI: 10.1007/s004390000406

Cite this article as:
Su, B., Xiao, C., Deka, R. et al. Hum Genet (2000) 107: 582. doi:10.1007/s004390000406

Abstract

By using 19 Y chromosome biallelic markers and 3 Y chromosome microsatellite markers, we analyzed the genetic structure of 31 indigenous Sino-Tibetan speaking populations (607 individuals) currently residing in East, Southeast, and South Asia. Our results showed that a T to C mutation at locus M122 is highly prevalent in almost all of the Sino-Tibetan populations, implying a strong genetic affinity among populations in the same language family. Furthermore, the extremely high frequency of H8, a haplotype derived from M122C, in the Sino-Tibetan speaking populations in the Himalayas including Tibet and northeast India indicated a strong bottleneck effect that occurred during a westward and then southward migration of the founding population of Tibeto-Burmans. We, therefore, postulate that the ancient people, who lived in the upper-middle Yellow River basin about 10,000 years ago and developed one of the earliest Neolithic cultures in East Asia, were the ancestors of modern Sino-Tibetan populations.

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Copyright information

© Springer-Verlag 2000