Human Genetics

, Volume 126, Issue 1, pp 91–99

Genetics of alcohol dependence


    • Department of Psychiatry, VAMC 116A2Yale University School of Medicine
    • Department of GeneticsYale University School of Medicine
    • Department of NeurobiologyYale University School of Medicine
    • VA Connecticut Healthcare System
  • Henry R. Kranzler
    • Department of PsychiatryUniversity of Connecticut School of Medicine
Review Article

DOI: 10.1007/s00439-009-0701-2

Cite this article as:
Gelernter, J. & Kranzler, H.R. Hum Genet (2009) 126: 91. doi:10.1007/s00439-009-0701-2


Alcohol dependence (AD), a genetically influenced phenotype, is extremely costly to individuals and to society in the United States and throughout the world, contributing to morbidity and mortality and a host of economic, interpersonal, and societal problems. Although until recently the only genes established to affect risk for AD were those encoding several alcohol metabolizing enzymes, there are now several other genes that can be regarded as confirmed risk loci, discovered through linkage and candidate gene association studies. While the mechanism of action of the effects of alcohol-metabolizing enzymes on AD risk is thought to be well understood, we are still in the early stages of understanding the physiology of other risk loci. Further, it is clear that only a small number of the many genes that influence risk for AD have been identified. Newer methodologies (e.g., genomewide association, study of copy number variation, and deep sequencing of candidate loci to identify rare risk variants) that have improved our understanding of other complex traits hold the promise of identifying a greater set of AD susceptibility loci.

Copyright information

© Springer-Verlag 2009