Short Report

Human Genetics

, Volume 121, Issue 5, pp 631-633

A strong association between human earwax-type and apocrine colostrum secretion from the mammary gland

  • Kiyonori MiuraAffiliated withDepartment of Obstetrics and Gynaecology, Nagasaki University Graduate School of Biomedical Sciences Email author 
  • , Koh-ichiro YoshiuraAffiliated withDepartment of Human Genetics, Nagasaki University Graduate School of Biomedical SciencesSORST, Japan Science and Technology Agency (JST)
  • , Shoko MiuraAffiliated withDepartment of Obstetrics and Gynaecology, Nagasaki University Graduate School of Biomedical SciencesSORST, Japan Science and Technology Agency (JST)
  • , Takako ShimadaAffiliated withDepartment of Obstetrics and Gynaecology, Nagasaki University Graduate School of Biomedical Sciences
  • , Kentaro YamasakiAffiliated withDepartment of Obstetrics and Gynaecology, Nagasaki University Graduate School of Biomedical Sciences
  • , Atsushi YoshidaAffiliated withDepartment of Obstetrics and Gynaecology, Nagasaki University Graduate School of Biomedical Sciences
  • , Daisuke NakayamaAffiliated withDepartment of Obstetrics and Gynaecology, Nagasaki University Graduate School of Biomedical Sciences
  • , Yoshisada ShibataAffiliated withDepartment of Radiation Epidemiology, Nagasaki University Graduate School of Biomedical Sciences
  • , Norio NiikawaAffiliated withDepartment of Human Genetics, Nagasaki University Graduate School of Biomedical SciencesSORST, Japan Science and Technology Agency (JST)
    • , Hideaki MasuzakiAffiliated withDepartment of Obstetrics and Gynaecology, Nagasaki University Graduate School of Biomedical Sciences

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Here we provided the first genetic evidence for an association between the degree of apocrine colostrum secretion and human earwax type. Genotyping at the earwax-type locus, rs17822931 within the ABCC11 gene, revealed that 155 of 225 Japanese women were dry-type and 70 wet-type. Frequency of women without colostrum among dry-type women was significantly higher than that among wet-type women (< 0.0002), and the measurable colostrum volume in dry-type women was significantly smaller than in wet-type women (P = 0.0341).

Keywords

Human earwax-type Colostrum secretion ABCC11 Polymorphism