Human Genetics

, Volume 121, Issue 5, pp 631–633

A strong association between human earwax-type and apocrine colostrum secretion from the mammary gland

  • Kiyonori Miura
  • Koh-ichiro Yoshiura
  • Shoko Miura
  • Takako Shimada
  • Kentaro Yamasaki
  • Atsushi Yoshida
  • Daisuke Nakayama
  • Yoshisada Shibata
  • Norio Niikawa
  • Hideaki Masuzaki
Short Report

DOI: 10.1007/s00439-007-0356-9

Cite this article as:
Miura, K., Yoshiura, K., Miura, S. et al. Hum Genet (2007) 121: 631. doi:10.1007/s00439-007-0356-9

Abstract

Here we provided the first genetic evidence for an association between the degree of apocrine colostrum secretion and human earwax type. Genotyping at the earwax-type locus, rs17822931 within the ABCC11 gene, revealed that 155 of 225 Japanese women were dry-type and 70 wet-type. Frequency of women without colostrum among dry-type women was significantly higher than that among wet-type women (< 0.0002), and the measurable colostrum volume in dry-type women was significantly smaller than in wet-type women (P = 0.0341).

Keywords

Human earwax-typeColostrum secretionABCC11Polymorphism

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Kiyonori Miura
    • 1
  • Koh-ichiro Yoshiura
    • 2
    • 4
  • Shoko Miura
    • 1
    • 4
  • Takako Shimada
    • 1
  • Kentaro Yamasaki
    • 1
  • Atsushi Yoshida
    • 1
  • Daisuke Nakayama
    • 1
  • Yoshisada Shibata
    • 3
  • Norio Niikawa
    • 2
    • 4
  • Hideaki Masuzaki
    • 1
  1. 1.Department of Obstetrics and Gynaecology Nagasaki University Graduate School of Biomedical SciencesNagasakiJapan
  2. 2.Department of Human Genetics Nagasaki University Graduate School of Biomedical SciencesNagasakiJapan
  3. 3.Department of Radiation Epidemiology Nagasaki University Graduate School of Biomedical SciencesNagasakiJapan
  4. 4.SORSTJapan Science and Technology Agency (JST)KawaguchiJapan